HitPredict

Interactor 1: DYN1 (Q05193)
Dynamin-1 (EC 3.6.5.5) (Dynamin) (Dynamin I)
Gene: DNM1

Interactor 2: SH3G2 (Q99962)
Endophilin-A1 (EEN-B1) (Endophilin-1) (SH3 domain protein 2A) (SH3 domain-containing GRB2-like protein 2)
Gene: SH3GL2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.63	0.60	0.619

Property	Details
Experiments	9341169, 15834155
Identification Methods	pull down, surface plasmon resonance
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0042995 - cell projection GO:0098793 - presynapse GO:0098978 - glutamatergic synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 864 Hs			1 352
+	Rn
		192351 DYN1_RAT (1-864): 0: 1081: 98.03		SH3G2_RAT (1-352): 2.12e-95: 289: 98.58
+	Mm
		760454 DYN1_MOUSE (1-845): 0: 1081: 99.65		SH3G2_MOUSE (1-352): 3.65e-95: 288: 98.86
+	Mm
		760455 DYN1_MOUSE (1-845): 0: 1081: 99.65		SH3G3_MOUSE (1-351): 3.62e-90: 276: 64.67
+	Rn
		192355 DYN1_RAT (1-864): 0: 1081: 98.03		SH3G3_RAT (1-352): 2.37e-87: 268: 65.06
+	Hs
		983404 DYN1_HUMAN (1-864): 0: 1087: 100.00		SH3G1_HUMAN (1-352): 1.41e-84: 262: 69.57
+	Rn
		193636 DYN1_RAT (1-864): 0: 1081: 98.03		SH3G1_RAT (1-352): 4.69e-84: 261: 69.57
+	Mm
		760453 DYN1_MOUSE (1-845): 0: 1081: 99.65		SH3G1_MOUSE (1-352): 4.74e-84: 261: 69.02
+	Mm
		760467 DYN1_MOUSE (1-845): 0: 1081: 99.65		SHLB1_MOUSE (10-347): 1.38e-72: 231: 24.79
+	Hs
		983392 DYN1_HUMAN (1-864): 0: 1087: 100.00		NOSTN_HUMAN (5-349): 7.39e-43: 157: 16.08
+	Mm
		760473 DYN2_MOUSE (1-860): 0: 1022: 79.13		SRC8_MOUSE (7-348): 9.78e-54: 187: 13.66
+	Hs
		924499 DYN1_HUMAN (1-864): 0: 1087: 100.00		GRB2_HUMAN (295-351): 1.51e-12: 67.8: 43.10
+	Rn
		599413 DYN1_RAT (1-864): 0: 1081: 98.03		ITSN1_RAT (12-349): 3.76e-13: 72.7: 13.51
+	Rn
		599402 DYN1_RAT (1-864): 0: 1081: 98.03		GRB2_RAT (295-351): 1.51e-12: 67.8: 43.10
+	Mm
		760450 DYN1_MOUSE (1-845): 0: 1081: 99.65		GRB2_MOUSE (295-351): 1.71e-12: 67.8: 43.10
+	Rn
		192739 DYN1_RAT (1-864): 0: 1081: 98.03		SRBS2_RAT (295-352): 1.15e-10: 65.1: 34.72
+	Mm
		760462 DYN1_MOUSE (1-845): 0: 1081: 99.65		SH3K1_MOUSE (280-347): 3.72e-10: 63.2: 44.00
+	Mm
		760474 DYN2_MOUSE (1-860): 0: 1022: 79.13		GRB2_MOUSE (295-351): 1.71e-12: 67.8: 43.10
+	Hs
		840663 DYN2_HUMAN (1-860): 0: 1021: 78.91		GRB2_HUMAN (295-351): 1.51e-12: 67.8: 43.10
+	Rn
		192740 DYN2_RAT (1-860): 0: 1021: 79.02		SRBS2_RAT (295-352): 1.15e-10: 65.1: 34.72
+	Mm
		760481 DYN2_MOUSE (1-860): 0: 1022: 79.13		SH3K1_MOUSE (280-347): 3.72e-10: 63.2: 44.00