HitPredict

Interactor 1: MAD1 (Q05195)
Max dimerization protein 1 (Max dimerizer 1) (Protein MAD)
Gene: MXD1

Interactor 2: HDAC2 (Q92769)
Histone deacetylase 2 (HD2) (EC 3.5.1.98) (Protein deacylase HDAC2) (EC 3.5.1.-)
Gene: HDAC2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

Property	Details
Experiments	9150134, 11101889
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000785 - chromatin GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 221 Hs			1 488
+	Hs
		840221 MXI1_HUMAN (7-207): 1.24e-66: 206: 58.53		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Hs
		983427 MAD1_HUMAN (1-221): 1.6e-77: 233: 100.00		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		840208 MXI1_HUMAN (7-207): 1.24e-66: 206: 58.53		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		347485 MYC_HUMAN (39-139): 6.1e-32: 122: 22.77		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Hs
		379673 MYCN_HUMAN (31-137): 2.13e-31: 121: 22.94		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Mm
		139901 MNT_MOUSE (38-169): 2.87e-39: 144: 26.00		HDAC1_MOUSE (1-443): 0: 645: 90.29
+	Hs
		1038660 MNT_HUMAN (38-169): 2.82e-36: 135: 24.67		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		898164 MAX_HUMAN (53-155): 4.73e-12: 63.6: 24.27		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Hs
		346718 MYC_HUMAN (39-139): 6.1e-32: 122: 22.77		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		379372 MYCN_HUMAN (31-137): 2.13e-31: 121: 22.94		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		177165 MYC_HUMAN (39-139): 6.1e-32: 122: 22.77		HDAC3_HUMAN (10-431): 0: 574: 58.26
+	Hs
		348135 MYC_HUMAN (39-139): 6.1e-32: 122: 22.77		HDAC6_HUMAN (11-363): 6.94e-102: 332: 24.04