HitPredict

Interactor 1: PTN12 (Q05209)
Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (PTP-PEST) (Protein-tyrosine phosphatase G1) (PTPG1)
Gene: PTPN12

Interactor 2: ACK1 (Q07912)
Activated CDC42 kinase 1 (ACK-1) (EC 2.7.10.2) (EC 2.7.11.1) (Tyrosine kinase non-receptor protein 2)
Gene: TNK2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	19167335
Identification Methods	phosphatase assay
Interaction Type	dephosphorylation reaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~Y_phosphatase
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 780 Hs			1 1038
+	Hs
		441194 PTPRC_HUMAN (13-678): 1.57e-143: 456: 19.30		ACK1_HUMAN (1-1038): 0: 805: 100.00
+	Hs
		983475 PTN12_HUMAN (1-780): 0: 586: 100.00		FAK1_HUMAN (6-692): 3.3e-131: 425: 21.01
+	Hs
		983487 PTN12_HUMAN (1-780): 0: 586: 100.00		ERBB4_HUMAN (84-754): 3.34e-128: 423: 24.17
+	Hs
		983495 PTN12_HUMAN (1-780): 0: 586: 100.00		LMTK1_HUMAN (84-959): 2.68e-126: 419: 21.75
+	Hs
		411687 PTN12_HUMAN (1-780): 0: 586: 100.00		LCK_HUMAN (1-398): 8.72e-125: 391: 30.08
+	Hs
		983483 PTN12_HUMAN (1-780): 0: 586: 100.00		FAK2_HUMAN (49-624): 1.48e-117: 387: 26.22
+	Mm
		728828 PTN12_MOUSE (1-780): 0: 560: 83.10		EGFR_MOUSE (94-606): 1.83e-120: 400: 27.77
+	Mm
		411913 PTPRC_MOUSE (13-686): 9.35e-150: 472: 18.93		LCK_MOUSE (1-398): 4.44e-125: 392: 30.58
+	Hs
		441169 PTPRC_HUMAN (13-678): 1.57e-143: 456: 19.30		SRC_HUMAN (1-400): 3.99e-127: 399: 31.42
+	Hs
		411950 PTPRC_HUMAN (13-678): 1.57e-143: 456: 19.30		FYN_HUMAN (1-400): 2.52e-126: 397: 30.18
+	Hs
		411557 PTPRC_HUMAN (13-678): 1.57e-143: 456: 19.30		LCK_HUMAN (1-398): 8.72e-125: 391: 30.08
+	Hs
		433528 PTPRC_HUMAN (13-678): 1.57e-143: 456: 19.30		LYN_HUMAN (92-388): 4.52e-112: 358: 36.79
+	Hs
		411900 PTN22_HUMAN (1-779): 6.27e-132: 413: 32.01		LCK_HUMAN (1-398): 8.72e-125: 391: 30.08
+	Hs
		338312 PTN12_HUMAN (1-780): 0: 586: 100.00		EGFR_HUMAN (105-387): 2.98e-55: 211: 39.58
+	Hs
		788986 PTN12_HUMAN (1-780): 0: 586: 100.00		TEC_HUMAN (121-391): 5.29e-51: 192: 39.64
+	Hs
		238399 PTN12_HUMAN (1-780): 0: 586: 100.00		JAK2_HUMAN (102-413): 4.21e-17: 89: 26.97
+	Hs
		337802 PTPRC_HUMAN (13-678): 1.57e-143: 456: 19.30		EGFR_HUMAN (105-387): 2.98e-55: 211: 39.58
+	Hs
		441187 PTPRC_HUMAN (13-678): 1.57e-143: 456: 19.30		TEC_HUMAN (121-391): 5.29e-51: 192: 39.64
+	Hs
		339171 PTN22_HUMAN (1-779): 6.27e-132: 413: 32.01		EGFR_HUMAN (105-387): 2.98e-55: 211: 39.58
+	Mm
		420376 PTPRC_MOUSE (13-686): 9.35e-150: 472: 18.93		JAK2_MOUSE (121-413): 1.58e-17: 90.5: 27.60