HitPredict

Interactor 1: PTN12 (Q05209)
Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (PTP-PEST) (Protein-tyrosine phosphatase G1) (PTPG1)
Gene: PTPN12

Interactor 2: FAK2 (Q14289)
Protein-tyrosine kinase 2-beta (EC 2.7.10.2) (Calcium-dependent tyrosine kinase) (CADTK) (Calcium-regulated non-receptor proline-rich tyrosine kinase) (Cell adhesion kinase beta) (CAK-beta) (CAKB) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Related adhesion focal tyrosine kinase) (RAFTK)
Gene: PTK2B

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	11337490
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~Y_phosphatase
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005925 - focal adhesion
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 780 Hs			1 1009
+	Hs
		983475 PTN12_HUMAN (1-780): 0: 586: 100.00		FAK1_HUMAN (39-1000): 0: 846: 44.25
+	Hs
		983487 PTN12_HUMAN (1-780): 0: 586: 100.00		ERBB4_HUMAN (240-925): 9.44e-128: 421: 22.59
+	Hs
		383760 PTN12_HUMAN (1-780): 0: 586: 100.00		ERBB2_HUMAN (286-908): 2.13e-124: 411: 21.96
+	Hs
		411687 PTN12_HUMAN (1-780): 0: 586: 100.00		LCK_HUMAN (208-694): 1.45e-123: 387: 27.18
+	Hs
		788986 PTN12_HUMAN (1-780): 0: 586: 100.00		TEC_HUMAN (301-688): 9.38e-118: 377: 26.46
+	Hs
		383545 PTPRC_HUMAN (13-678): 1.57e-143: 456: 19.30		ERBB2_HUMAN (286-908): 2.13e-124: 411: 21.96
+	Mm
		411913 PTPRC_MOUSE (13-686): 9.35e-150: 472: 18.93		LCK_MOUSE (208-694): 4.72e-124: 389: 27.59
+	Hs
		411557 PTPRC_HUMAN (13-678): 1.57e-143: 456: 19.30		LCK_HUMAN (208-694): 1.45e-123: 387: 27.18
+	Hs
		337361 PTN6_HUMAN (7-361): 1.95e-132: 407: 31.25		ABL1_HUMAN (264-885): 2.55e-133: 432: 23.56
+	Hs
		441187 PTPRC_HUMAN (13-678): 1.57e-143: 456: 19.30		TEC_HUMAN (301-688): 9.38e-118: 377: 26.46
+	Hs
		441169 PTPRC_HUMAN (13-678): 1.57e-143: 456: 19.30		SRC_HUMAN (288-695): 5.62e-117: 371: 27.74
+	Hs
		411950 PTPRC_HUMAN (13-678): 1.57e-143: 456: 19.30		FYN_HUMAN (288-695): 1.25e-116: 370: 29.68
+	Hs
		384039 PTN22_HUMAN (1-779): 6.27e-132: 413: 32.01		ERBB2_HUMAN (286-908): 2.13e-124: 411: 21.96
+	Hs
		383611 PTPRB_HUMAN (7-314): 1.22e-123: 410: 29.62		ERBB2_HUMAN (286-908): 2.13e-124: 411: 21.96
+	Hs
		383633 PTN6_HUMAN (7-361): 1.95e-132: 407: 31.25		ERBB2_HUMAN (286-908): 2.13e-124: 411: 21.96
+	Hs
		411900 PTN22_HUMAN (1-779): 6.27e-132: 413: 32.01		LCK_HUMAN (208-694): 1.45e-123: 387: 27.18
+	Hs
		411596 PTPRB_HUMAN (7-314): 1.22e-123: 410: 29.62		LCK_HUMAN (208-694): 1.45e-123: 387: 27.18
+	Hs
		411612 PTN6_HUMAN (7-361): 1.95e-132: 407: 31.25		LCK_HUMAN (208-694): 1.45e-123: 387: 27.18
+	Hs
		616906 PTPRB_HUMAN (7-314): 1.22e-123: 410: 29.62		TEC_HUMAN (301-688): 9.38e-118: 377: 26.46
+	Hs
		523222 PTN22_HUMAN (1-779): 6.27e-132: 413: 32.01		SRC_HUMAN (288-695): 5.62e-117: 371: 27.74