HitPredict

Interactor 1: PTN12 (Q05209)
Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (PTP-PEST) (Protein-tyrosine phosphatase G1) (PTPG1)
Gene: PTPN12

Interactor 2: LMTK2 (Q8IWU2)
Serine/threonine-protein kinase LMTK2 (EC 2.7.11.1) (Apoptosis-associated tyrosine kinase 2) (Brain-enriched kinase) (hBREK) (CDK5/p35-regulated kinase) (CPRK) (Kinase/phosphatase/inhibitor 2) (Lemur tyrosine kinase 2) (Serine/threonine-protein kinase KPI-2)
Gene: LMTK2

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	0.80	0.625

Property	Details
Experiments	28065597
Identification Methods	two hybrid, ubiquitin reconstruction
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~Y_phosphatase
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 780 Hs			1 1503
+	Hs
		983495 PTN12_HUMAN (1-780): 0: 586: 100.00		LMTK1_HUMAN (14-1500): 0: 702: 29.02
+	Hs
		983487 PTN12_HUMAN (1-780): 0: 586: 100.00		ERBB4_HUMAN (17-748): 3.15e-132: 444: 18.30
+	Hs
		601500 PTN12_HUMAN (1-780): 0: 586: 100.00		FGFR2_HUMAN (33-454): 4.84e-123: 406: 20.31
+	Hs
		983483 PTN12_HUMAN (1-780): 0: 586: 100.00		FAK2_HUMAN (66-696): 3.04e-118: 398: 17.76
+	Hs
		433528 PTPRC_HUMAN (13-678): 1.57e-143: 456: 19.30		LYN_HUMAN (86-421): 2.69e-109: 358: 22.19
+	Hs
		337361 PTN6_HUMAN (7-361): 1.95e-132: 407: 31.25		ABL1_HUMAN (84-931): 1.76e-117: 399: 18.90
+	Hs
		384692 PTN12_HUMAN (1-780): 0: 586: 100.00		NTRK1_HUMAN (131-410): 1.29e-36: 152: 33.33
+	Hs
		411361 PTN12_HUMAN (1-780): 0: 586: 100.00		INSR_HUMAN (93-407): 2.85e-34: 145: 32.82
+	Hs
		435618 PTN12_HUMAN (1-780): 0: 586: 100.00		IGF1R_HUMAN (131-399): 1.23e-33: 144: 33.33
+	Hs
		788986 PTN12_HUMAN (1-780): 0: 586: 100.00		TEC_HUMAN (123-410): 1.39e-31: 134: 30.61
+	Hs
		983479 PTN12_HUMAN (1-780): 0: 586: 100.00		PTK7_HUMAN (28-403): 9.63e-31: 134: 29.05
+	Hs
		384127 PTPRC_HUMAN (13-678): 1.57e-143: 456: 19.30		NTRK1_HUMAN (131-410): 1.29e-36: 152: 33.33
+	Hs
		411278 PTPRC_HUMAN (13-678): 1.57e-143: 456: 19.30		INSR_HUMAN (93-407): 2.85e-34: 145: 32.82
+	Hs
		441187 PTPRC_HUMAN (13-678): 1.57e-143: 456: 19.30		TEC_HUMAN (123-410): 1.39e-31: 134: 30.61
+	Hs
		385757 PTN22_HUMAN (1-779): 6.27e-132: 413: 32.01		NTRK1_HUMAN (131-410): 1.29e-36: 152: 33.33
+	Hs
		384278 PTPRB_HUMAN (7-314): 1.22e-123: 410: 29.62		NTRK1_HUMAN (131-410): 1.29e-36: 152: 33.33
+	Hs
		384330 PTN6_HUMAN (7-361): 1.95e-132: 407: 31.25		NTRK1_HUMAN (131-410): 1.29e-36: 152: 33.33
+	Hs
		411297 PTPRB_HUMAN (7-314): 1.22e-123: 410: 29.62		INSR_HUMAN (93-407): 2.85e-34: 145: 32.82
+	Hs
		411311 PTN6_HUMAN (7-361): 1.95e-132: 407: 31.25		INSR_HUMAN (93-407): 2.85e-34: 145: 32.82
+	Hs
		616906 PTPRB_HUMAN (7-314): 1.22e-123: 410: 29.62		TEC_HUMAN (123-410): 1.39e-31: 134: 30.61