HitPredict

Interactor 1: KPCZ (Q05513)
Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta)
Gene: PRKCZ

Interactor 2: L2GL2 (Q6P1M3)
LLGL scribble cell polarity complex component 2 (HGL) (Lethal(2) giant larvae protein homolog 2)
Gene: LLGL2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.93	0.60	0.750

Property	Details
Experiments	24366813, 33961781, 25852190, 28514442, 29491746, 31980649, 32707033, unassigned2173
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0045197 - establishment or maintenance of epithelial cell apical/basal polarity
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 592 Hs			1 1020
+	Hs
		784030 KPCI_HUMAN (1-592): 0: 654: 69.87		L2GL2_HUMAN (1-1020): 0: 1275: 100.00
+	Mm
		1111901 KPCI_MOUSE (1-592): 0: 655: 69.70		L2GL2_MOUSE (1-1020): 0: 1252: 90.17
+	Hs
		983844 KPCZ_HUMAN (1-592): 0: 688: 100.00		L2GL1_HUMAN (3-965): 0: 1085: 56.79
+	Mm
		973812 KPCZ_MOUSE (1-592): 0: 681: 95.61		L2GL1_MOUSE (3-964): 0: 1090: 56.66
+	Mm
		1143282 KPCI_MOUSE (1-592): 0: 655: 69.70		L2GL1_MOUSE (3-964): 0: 1090: 56.66
+	Hs
		784012 KPCI_HUMAN (1-592): 0: 654: 69.87		L2GL1_HUMAN (3-965): 0: 1085: 56.79
+	Rn
		1144332 AKT3_RAT (171-582): 3.93e-152: 447: 36.53		L2GL1_RAT (3-964): 0: 1091: 56.66
+	Hs
		568673 KAPCA_HUMAN (219-578): 5.07e-143: 419: 33.06		L2GL1_HUMAN (3-965): 0: 1085: 56.79
+	Dm
		54639 APKC_DROME (3-592): 0: 615: 61.99		L2GL_DROME (1-944): 0: 842: 35.12
+	Ce
		106868 KPC3_CAEEL (5-592): 0: 586: 54.53		G5EEI1_CAEEL (1-924): 0: 710: 20.00