HitPredict

Interactor 1: ZBT16 (Q05516)
Zinc finger and BTB domain-containing protein 16 (Promyelocytic leukemia zinc finger protein) (Zinc finger protein 145) (Zinc finger protein PLZF)
Gene: ZBTB16

Interactor 2: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	22632832
Identification Methods	pull down
Interaction Type	physical association

Property	Details
Interacting Pfam domains	BTB~Cullin
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005829 - cytosol GO:0016567 - protein ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 673 Hs			1 768
+	Hs
		1042371 ZN184_HUMAN (147-673): 0: 539: 23.06		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		1041826 Z585A_HUMAN (125-652): 2.26e-174: 517: 23.11		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		1042724 ZN624_HUMAN (121-673): 5.07e-170: 509: 22.55		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		983757 ZNF91_HUMAN (141-673): 5.61e-165: 506: 21.95		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		563252 ZNF12_HUMAN (215-654): 2.9e-152: 458: 25.83		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		1042799 ZN229_HUMAN (119-673): 1.23e-142: 437: 18.70		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		1042050 ZN565_HUMAN (371-654): 2.3e-135: 409: 35.44		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		1041813 ZN544_HUMAN (144-673): 2.29e-120: 377: 21.73		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		565092 ZNF7_HUMAN (267-598): 1.13e-107: 342: 26.48		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		1042314 ZN583_HUMAN (387-673): 1.36e-108: 341: 27.78		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		1041998 ZN100_HUMAN (432-673): 1.73e-105: 332: 34.71		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		1042010 ZN567_HUMAN (187-544): 1.16e-96: 312: 19.14		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		1041764 ZN658_HUMAN (145-673): 1.46e-81: 281: 16.67		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		1042144 ZN480_HUMAN (140-514): 5.6e-85: 278: 16.50		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		846676 ZNF84_HUMAN (110-431): 1.84e-61: 220: 11.59		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		1041578 ZN268_HUMAN (110-431): 5.31e-59: 215: 10.91		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		73009 ZN879_HUMAN (110-399): 5.12e-52: 190: 8.80		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Mm
		1113176 Q3UQ17_MOUSE (123-489): 1.28e-50: 189: 11.52		CUL3_MOUSE (1-768): 0: 949: 99.48
+	Hs
		1042048 ZN557_HUMAN (385-625): 7.55e-50: 181: 38.17		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		549161 ZN250_HUMAN (110-373): 2.66e-40: 157: 8.93		CUL3_HUMAN (1-768): 0: 951: 100.00