HitPredict

Interactor 1: SGPL (Q05567)
Sphingosine-1-phosphate lyase (S1PL) (SP-lyase) (ySPL) (EC 4.1.2.-) (EC 4.1.2.27) (Bestowed of sphingosine tolerance 1) (Sphingosine-1-phosphate aldolase)
Gene: DPL1

Interactor 2: SGPL (Q05567)
Sphingosine-1-phosphate lyase (S1PL) (SP-lyase) (ySPL) (EC 4.1.2.-) (EC 4.1.2.27) (Bestowed of sphingosine tolerance 1) (Sphingosine-1-phosphate aldolase)
Gene: DPL1

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.75 1.00 0.867

The method score is based on:

Property Details
Experiments 18487605, 22940862, 20696404
Identification Methods x-ray crystallography, affinity chromatography technology, molecular sieving, cosedimentation in solution
Interaction Type association, physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains Pyridoxal_deC~Pyridoxal_deC
Common GO terms GO:0004068 - aspartate 1-decarboxylase activity
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0006665 - sphingolipid metabolic process
GO:0008117 - sphinganine-1-phosphate aldolase activity
and 8 others

more...
Homologous interactions 17

Homologous interactions

Color coding for hit scores

1 589
Sc

1 589
+ Hs
+ Rn
+ Hs
+ Rn
+ Hs
+ Hs
+ At
+ Hs
+ At
+ Ec
+ Ce
+ Ce
+ Sc
+ Ec
+ Ec
+ Ec
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024