HitPredict

Interactor 1: CALD1 (Q05682)
Caldesmon (CDM)
Gene: CALD1

Interactor 2: SPTN1 (Q13813)
Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin) (Fodrin alpha chain) (Spectrin, non-erythroid alpha subunit)
Gene: SPTAN1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.621

Property	Details
Experiments	30021884, 35271311
Identification Methods	proximity labelling technology, affinity chromatography technology, cross-linking study, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003779 - actin binding GO:0005516 - calmodulin binding GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0045296 - cadherin binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 793 Hs			1 2472
+	Hs
		1045471 MY18A_HUMAN (9-628): 1.86e-28: 125: 15.98		SPTN1_HUMAN (1-2472): 0: 714: 100.00
+	Hs
		1045423 ITSN1_HUMAN (235-636): 6.18e-27: 120: 21.34		SPTN1_HUMAN (1-2472): 0: 714: 100.00
+	Mm
		93541 DESP_MOUSE (13-637): 1.8e-22: 105: 13.96		SPTA1_MOUSE (1-2472): 2.17e-161: 558: 54.20
+	Hs
		164608 CALD1_HUMAN (1-793): 4.35e-43: 169: 100.00		SPTN2_HUMAN (141-1932): 1.25e-65: 250: 20.41
+	Hs
		164647 MY18A_HUMAN (9-628): 1.86e-28: 125: 15.98		SPTN2_HUMAN (141-1932): 1.25e-65: 250: 20.41
+	Hs
		164575 MYH9_HUMAN (2-631): 8.69e-22: 103: 10.87		SPTN2_HUMAN (141-1932): 1.25e-65: 250: 20.41
+	Hs
		963299 CALD1_HUMAN (1-793): 4.35e-43: 169: 100.00		SPTB2_HUMAN (2-1043): 1.4e-42: 174: 20.52
+	Hs
		963381 MY18A_HUMAN (9-628): 1.86e-28: 125: 15.98		SPTB2_HUMAN (2-1043): 1.4e-42: 174: 20.52
+	Hs
		963335 ITSN1_HUMAN (235-636): 6.18e-27: 120: 21.34		SPTB2_HUMAN (2-1043): 1.4e-42: 174: 20.52
+	Hs
		1068548 GRDN_HUMAN (28-793): 9.97e-36: 148: 12.77		PLEC_HUMAN (16-1253): 4.4e-31: 137: 9.18
+	Hs
		974117 MY18A_HUMAN (9-628): 1.86e-28: 125: 15.98		DYST_HUMAN (5-2410): 1.41e-35: 152: 10.59
+	Hs
		974083 ITSN1_HUMAN (235-636): 6.18e-27: 120: 21.34		DYST_HUMAN (5-2410): 1.41e-35: 152: 10.59
+	Mm
		93578 DESP_MOUSE (13-637): 1.8e-22: 105: 13.96		PLEC_MOUSE (1-1250): 7.03e-38: 159: 10.80
+	Hs
		1068617 MY18A_HUMAN (9-628): 1.86e-28: 125: 15.98		PLEC_HUMAN (16-1253): 4.4e-31: 137: 9.18
+	Hs
		211569 CALD1_HUMAN (1-793): 4.35e-43: 169: 100.00		ACTN4_HUMAN (1843-2219): 1.15e-09: 66.2: 20.15
+	Hs
		1113839 GRDN_HUMAN (28-793): 9.97e-36: 148: 12.77		CP250_HUMAN (1768-2439): 4.39e-10: 67.7: 8.94
+	Hs
		110636 MYH9_HUMAN (2-631): 8.69e-22: 103: 10.87		H3BPE1_HUMAN (9-1261): 4.01e-18: 94.7: 12.35
+	Hs
		211632 MY18A_HUMAN (9-628): 1.86e-28: 125: 15.98		ACTN4_HUMAN (1843-2219): 1.15e-09: 66.2: 20.15
+	Hs
		521484 MYH9_HUMAN (2-631): 8.69e-22: 103: 10.87		ACTN1_HUMAN (1862-2210): 3.16e-11: 71.2: 22.25
+	Hs
		211515 MYH9_HUMAN (2-631): 8.69e-22: 103: 10.87		ACTN4_HUMAN (1843-2219): 1.15e-09: 66.2: 20.15