HitPredict

Interactor 1: HME1 (Q05925)
Homeobox protein engrailed-1 (Homeobox protein en-1) (Hu-En-1)
Gene: EN1

Interactor 2: TLE5 (Q08117)
TLE family member 5 (Amino-terminal enhancer of split) (Amino enhancer of split) (Gp130-associated protein GAM) (Grg-5) (Groucho-related protein 5) (Protein ESP1) (Protein GRG) (TLE family member 5, transcriptional modulator)
Gene: TLE5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	33961781, 35140242
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0001501 - skeletal system development GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 392 Hs			1 197
+	Hs
		980926 HME1_HUMAN (1-392): 1.5e-35: 136: 100.00		TLE4_HUMAN (2-191): 3.57e-112: 338: 68.59
+	Hs
		980587 HME1_HUMAN (1-392): 1.5e-35: 136: 100.00		TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50
+	Hs
		829830 HXA1_HUMAN (140-376): 1.7e-32: 126: 21.99		TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50
+	Hs
		980732 HME1_HUMAN (1-392): 1.5e-35: 136: 100.00		TLE3_HUMAN (2-197): 3.95e-105: 320: 61.50
+	Hs
		585946 HME2_HUMAN (44-392): 3.87e-26: 109: 42.98		TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50
+	Hs
		980663 HESX1_HUMAN (232-375): 1.5e-27: 109: 26.39		TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50
+	Hs
		829834 HXA1_HUMAN (140-376): 1.7e-32: 126: 21.99		TLE5_HUMAN (1-197): 3.1e-101: 292: 100.00
+	Hs
		447242 HXB5_HUMAN (196-366): 1.41e-31: 122: 28.07		TLE5_HUMAN (1-197): 3.1e-101: 292: 100.00
+	Hs
		980676 HME1_HUMAN (1-392): 1.5e-35: 136: 100.00		TLE2_HUMAN (2-149): 6.71e-80: 253: 71.62
+	Hs
		980675 EMX2_HUMAN (156-391): 2.59e-32: 123: 24.79		TLE2_HUMAN (2-149): 6.71e-80: 253: 71.62
+	Dm
		558391 Q9NHP8_DROME (3-391): 2.9e-46: 167: 17.18		GROU_DROME (2-163): 3.54e-59: 198: 54.44
+	Dm
		403512 HMIN_DROME (265-386): 3.58e-45: 165: 60.27		GROU_DROME (2-163): 3.54e-59: 198: 54.44
+	Dm
		367240 HMEN_DROME (221-391): 1.93e-32: 130: 50.58		GROU_DROME (2-163): 3.54e-59: 198: 54.44
+	Dm
		558357 VND_DROME (3-380): 8.25e-32: 129: 16.92		GROU_DROME (2-163): 3.54e-59: 198: 54.44
+	Dm
		558366 UBX_DROME (180-361): 8.35e-29: 117: 20.67		GROU_DROME (2-163): 3.54e-59: 198: 54.44
+	Dm
		558365 GSC_DROME (20-375): 8.36e-27: 112: 15.45		GROU_DROME (2-163): 3.54e-59: 198: 54.44
+	Ce
		137666 HM16_CAEEL (254-364): 7.96e-38: 136: 57.27		UNC37_CAEEL (18-160): 8.43e-43: 153: 28.47
+	Ce
		108144 G5EGE2_CAEEL (285-368): 2.26e-30: 118: 35.96		UNC37_CAEEL (18-160): 8.43e-43: 153: 28.47
+	Ce
		137665 UNC4_CAEEL (244-386): 4.77e-28: 112: 20.55		UNC37_CAEEL (18-160): 8.43e-43: 153: 28.47
+	Ce
		137664 HM19_CAEEL (293-378): 1.9e-27: 109: 34.88		UNC37_CAEEL (18-160): 8.43e-43: 153: 28.47