HitPredict

Interactor 1: PTN11 (Q06124)
Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1D) (PTP-1D) (Protein-tyrosine phosphatase 2C) (PTP-2C) (SH-PTP2) (SHP-2) (Shp2) (SH-PTP3)
Gene: PTPN11

Interactor 2: NTRK3 (Q16288)
NT-3 growth factor receptor (EC 2.7.10.1) (GP145-TrkC) (Trk-C) (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase)
Gene: NTRK3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	35384245
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	LRR_8~SH2, PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~Y_phosphatase
Common GO terms	GO:0007507 - heart development
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 593 Hs			1 839
+	Hs
		985963 PTN11_HUMAN (1-593): 0: 581: 100.00		NTRK2_HUMAN (6-839): 0: 557: 52.87
+	Mm
		546284 PTN11_MOUSE (1-593): 0: 580: 99.49		NTRK2_MOUSE (6-839): 0: 555: 53.29
+	Rn
		783507 PTN11_RAT (1-593): 0: 578: 98.99		NTRK2_RAT (6-839): 0: 557: 52.88
+	Hs
		384697 PTN11_HUMAN (1-593): 0: 581: 100.00		NTRK1_HUMAN (16-839): 8.14e-173: 520: 46.75
+	Hs
		609260 PTN11_HUMAN (1-593): 0: 581: 100.00		FGFR3_HUMAN (140-838): 3.83e-170: 514: 23.73
+	Hs
		601501 PTN11_HUMAN (1-593): 0: 581: 100.00		FGFR2_HUMAN (203-838): 1.97e-168: 510: 24.89
+	Hs
		507959 PTN11_HUMAN (1-593): 0: 581: 100.00		FGFR1_HUMAN (162-838): 5.94e-163: 496: 23.43
+	Hs
		384330 PTN6_HUMAN (6-593): 0: 531: 55.27		NTRK1_HUMAN (16-839): 8.14e-173: 520: 46.75
+	Hs
		607949 PTN11_HUMAN (1-593): 0: 581: 100.00		FGFR4_HUMAN (166-837): 6.43e-152: 466: 24.57
+	Hs
		601466 PTN6_HUMAN (6-593): 0: 531: 55.27		FGFR2_HUMAN (203-838): 1.97e-168: 510: 24.89
+	Hs
		434178 PTN11_HUMAN (1-593): 0: 581: 100.00		RET_HUMAN (282-837): 1.5e-108: 360: 25.76
+	Hs
		985944 PTN11_HUMAN (1-593): 0: 581: 100.00		DDR1_HUMAN (535-824): 9.4e-68: 244: 43.63
+	Hs
		968364 PTN11_HUMAN (1-593): 0: 581: 100.00		ROR2_HUMAN (522-828): 2.97e-67: 243: 41.56
+	Hs
		411363 PTN11_HUMAN (1-593): 0: 581: 100.00		INSR_HUMAN (513-824): 1.34e-64: 238: 39.43
+	Hs
		435620 PTN11_HUMAN (1-593): 0: 581: 100.00		IGF1R_HUMAN (513-820): 3.56e-64: 236: 39.16
+	Rn
		783510 PTN11_RAT (1-593): 0: 578: 98.99		T2CB11_RAT (513-824): 3.31e-62: 230: 38.80
+	Hs
		986056 PTN11_HUMAN (1-593): 0: 581: 100.00		ALK_HUMAN (513-816): 2.78e-59: 222: 39.03
+	Hs
		411311 PTN6_HUMAN (6-593): 0: 531: 55.27		INSR_HUMAN (513-824): 1.34e-64: 238: 39.43
+	Hs
		435549 PTN6_HUMAN (6-593): 0: 531: 55.27		IGF1R_HUMAN (513-820): 3.56e-64: 236: 39.16
+	Hs
		985950 PTN11_HUMAN (1-593): 0: 581: 100.00		PTK7_HUMAN (215-380): 9.02e-12: 71.3: 17.34