HitPredict

Interactor 1: PTN11 (Q06124)
Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1D) (PTP-1D) (Protein-tyrosine phosphatase 2C) (PTP-2C) (SH-PTP2) (SHP-2) (Shp2) (SH-PTP3)
Gene: PTPN11

Interactor 2: NTRK2 (Q16620)
BDNF/NT-3 growth factors receptor (EC 2.7.10.1) (GP145-TrkB) (Trk-B) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (Tropomyosin-related kinase B)
Gene: NTRK2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	LRR_8~SH2, PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~Y_phosphatase
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 593 Hs			1 822
+	Mm
		546284 PTN11_MOUSE (1-593): 0: 580: 99.49		NTRK2_MOUSE (1-822): 0: 631: 93.92
+	Rn
		783507 PTN11_RAT (1-593): 0: 578: 98.99		NTRK2_RAT (1-822): 0: 622: 93.55
+	Hs
		985962 PTN11_HUMAN (1-593): 0: 581: 100.00		NTRK3_HUMAN (13-822): 1.98e-178: 536: 52.84
+	Hs
		607949 PTN11_HUMAN (1-593): 0: 581: 100.00		FGFR4_HUMAN (152-820): 3.01e-178: 534: 24.68
+	Hs
		609260 PTN11_HUMAN (1-593): 0: 581: 100.00		FGFR3_HUMAN (128-822): 1.4e-170: 514: 24.45
+	Hs
		384697 PTN11_HUMAN (1-593): 0: 581: 100.00		NTRK1_HUMAN (5-822): 2.36e-170: 513: 45.85
+	Hs
		507959 PTN11_HUMAN (1-593): 0: 581: 100.00		FGFR1_HUMAN (180-821): 3.75e-164: 498: 23.77
+	Hs
		601501 PTN11_HUMAN (1-593): 0: 581: 100.00		FGFR2_HUMAN (120-821): 4.81e-164: 498: 23.04
+	Hs
		384330 PTN6_HUMAN (6-593): 0: 531: 55.27		NTRK1_HUMAN (5-822): 2.36e-170: 513: 45.85
+	Hs
		665220 PTN11_HUMAN (1-593): 0: 581: 100.00		EPHA2_HUMAN (148-822): 4.29e-141: 443: 22.43
+	Hs
		434178 PTN11_HUMAN (1-593): 0: 581: 100.00		RET_HUMAN (436-820): 1.09e-115: 379: 33.00
+	Hs
		985944 PTN11_HUMAN (1-593): 0: 581: 100.00		DDR1_HUMAN (535-807): 1.28e-74: 263: 47.37
+	Hs
		435620 PTN11_HUMAN (1-593): 0: 581: 100.00		IGF1R_HUMAN (513-797): 1.01e-70: 256: 43.95
+	Hs
		411363 PTN11_HUMAN (1-593): 0: 581: 100.00		INSR_HUMAN (513-809): 2.11e-70: 254: 43.38
+	Hs
		968364 PTN11_HUMAN (1-593): 0: 581: 100.00		ROR2_HUMAN (530-808): 1.44e-69: 249: 44.52
+	Rn
		783510 PTN11_RAT (1-593): 0: 578: 98.99		T2CB11_RAT (513-809): 8.4e-68: 247: 42.72
+	Hs
		986056 PTN11_HUMAN (1-593): 0: 581: 100.00		ALK_HUMAN (513-799): 4.96e-64: 236: 41.44
+	Hs
		666580 PTN11_HUMAN (1-593): 0: 581: 100.00		LTK_HUMAN (506-808): 6.29e-61: 223: 38.07
+	Hs
		411311 PTN6_HUMAN (6-593): 0: 531: 55.27		INSR_HUMAN (513-809): 2.11e-70: 254: 43.38
+	Hs
		985950 PTN11_HUMAN (1-593): 0: 581: 100.00		PTK7_HUMAN (170-408): 1.89e-11: 70.1: 16.60