HitPredict

Interactor 1: PTN11 (Q06124)
Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1D) (PTP-1D) (Protein-tyrosine phosphatase 2C) (PTP-2C) (SH-PTP2) (SHP-2) (Shp2) (SH-PTP3)
Gene: PTPN11

Interactor 2: LMTK1 (Q6ZMQ8)
Serine/threonine-protein kinase LMTK1 (EC 2.7.11.1) (Apoptosis-associated tyrosine kinase) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (Lemur tyrosine kinase 1) (p35-binding protein) (p35BP)
Gene: AATK

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	1.00	0.698

Property	Details
Experiments	28065597
Identification Methods	two hybrid, ubiquitin reconstruction
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~Y_phosphatase
Common GO terms	GO:0007420 - brain development
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 593 Hs			1 1374
+	Mm
		337619 PTN11_MOUSE (1-593): 0: 580: 99.49		ABL1_MOUSE (113-878): 1.89e-124: 416: 19.42
+	Hs
		601501 PTN11_HUMAN (1-593): 0: 581: 100.00		FGFR2_HUMAN (17-456): 6.43e-126: 412: 19.75
+	Hs
		609260 PTN11_HUMAN (1-593): 0: 581: 100.00		FGFR3_HUMAN (29-448): 5.82e-123: 403: 23.42
+	Hs
		507959 PTN11_HUMAN (1-593): 0: 581: 100.00		FGFR1_HUMAN (28-460): 6.26e-120: 396: 21.00
+	Hs
		985962 PTN11_HUMAN (1-593): 0: 581: 100.00		NTRK3_HUMAN (24-398): 5.5e-110: 369: 25.54
+	Hs
		872429 PTN11_HUMAN (1-593): 0: 581: 100.00		EPHA5_HUMAN (12-404): 9.44e-107: 365: 22.68
+	Mm
		719300 PTN11_MOUSE (1-593): 0: 580: 99.49		TIE2_MOUSE (7-404): 6.13e-106: 364: 24.40
+	Mm
		546284 PTN11_MOUSE (1-593): 0: 580: 99.49		NTRK2_MOUSE (30-400): 1.89e-106: 359: 28.03
+	Hs
		985963 PTN11_HUMAN (1-593): 0: 581: 100.00		NTRK2_HUMAN (30-400): 4.89e-106: 357: 27.78
+	Rn
		783507 PTN11_RAT (1-593): 0: 578: 98.99		NTRK2_RAT (30-400): 2.03e-106: 359: 28.03
+	Hs
		412146 PTN11_HUMAN (1-593): 0: 581: 100.00		FYN_HUMAN (104-408): 1.36e-104: 344: 30.07
+	Hs
		411363 PTN11_HUMAN (1-593): 0: 581: 100.00		INSR_HUMAN (111-395): 4.12e-41: 167: 36.27
+	Hs
		435620 PTN11_HUMAN (1-593): 0: 581: 100.00		IGF1R_HUMAN (119-391): 2.65e-38: 159: 34.51
+	Rn
		783510 PTN11_RAT (1-593): 0: 578: 98.99		T2CB11_RAT (111-395): 8.36e-39: 160: 35.25
+	Hs
		445845 PTN11_HUMAN (1-593): 0: 581: 100.00		ROS1_HUMAN (131-392): 2.54e-37: 156: 34.91
+	Hs
		985950 PTN11_HUMAN (1-593): 0: 581: 100.00		PTK7_HUMAN (32-391): 2.34e-37: 155: 31.90
+	Hs
		384697 PTN11_HUMAN (1-593): 0: 581: 100.00		NTRK1_HUMAN (120-398): 5.02e-34: 143: 32.77
+	Hs
		986056 PTN11_HUMAN (1-593): 0: 581: 100.00		ALK_HUMAN (109-386): 2.69e-32: 139: 32.99
+	Hs
		713788 PTN11_HUMAN (1-593): 0: 581: 100.00		RYK_HUMAN (96-403): 1.66e-31: 134: 30.56
+	Hs
		337361 PTN6_HUMAN (6-593): 0: 531: 55.27		ABL1_HUMAN (588-1118): 4.91e-10: 66.4: 13.32