HitPredict

Interactor 1: PTN11 (Q06124)
Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1D) (PTP-1D) (Protein-tyrosine phosphatase 2C) (PTP-2C) (SH-PTP2) (SHP-2) (Shp2) (SH-PTP3)
Gene: PTPN11

Interactor 2: GAB3 (Q8WWW8)
GRB2-associated-binding protein 3 (GRB2-associated binder 3) (Growth factor receptor bound protein 2-associated protein 3)
Gene: GAB3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	11739737
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 593 Hs			1 586
+	Hs
		986059 PTN11_HUMAN (1-593): 0: 581: 100.00		GAB2_HUMAN (2-585): 1.27e-75: 255: 31.29
+	Mm
		719323 PTN11_MOUSE (1-593): 0: 580: 99.49		GAB2_MOUSE (2-585): 2.96e-68: 235: 32.62
+	Mm
		719303 PTN11_MOUSE (1-593): 0: 580: 99.49		Q3ZB59_MOUSE (2-585): 2.2e-67: 233: 32.47
+	Hs
		665968 PTN6_HUMAN (6-593): 0: 531: 55.27		GAB2_HUMAN (2-585): 1.27e-75: 255: 31.29
+	Mm
		719319 PTN11_MOUSE (1-593): 0: 580: 99.49		GAB1_MOUSE (1-585): 1.34e-51: 190: 27.44
+	Hs
		985952 PTN11_HUMAN (1-593): 0: 581: 100.00		GAB1_HUMAN (1-585): 3.28e-51: 189: 26.37
+	Mm
		665998 PTN6_MOUSE (6-583): 0: 530: 55.94		GAB2_MOUSE (2-585): 2.96e-68: 235: 32.62
+	Hs
		665934 PTN6_HUMAN (6-593): 0: 531: 55.27		CNKR1_HUMAN (4-312): 1.98e-41: 161: 17.61
+	Hs
		665957 PTN6_HUMAN (6-593): 0: 531: 55.27		PKHA2_HUMAN (2-216): 1.06e-30: 126: 15.35
+	Hs
		616917 PTPRB_HUMAN (147-555): 2.35e-115: 379: 27.91		GAB1_HUMAN (1-585): 3.28e-51: 189: 26.37
+	Hs
		1020092 PTPRJ_HUMAN (146-528): 1.52e-109: 359: 30.55		GAB1_HUMAN (1-585): 3.28e-51: 189: 26.37
+	Hs
		577020 PTPRA_HUMAN (33-522): 7.08e-110: 349: 23.72		GAB1_HUMAN (1-585): 3.28e-51: 189: 26.37
+	Hs
		1020106 PTPRJ_HUMAN (146-528): 1.52e-109: 359: 30.55		CNKR1_HUMAN (4-312): 1.98e-41: 161: 17.61
+	Hs
		1281530 PTN18_HUMAN (231-579): 6.42e-111: 341: 32.32		CNKR1_HUMAN (4-312): 1.98e-41: 161: 17.61
+	Hs
		441197 PTPRC_HUMAN (33-579): 2.25e-85: 291: 18.29		GAB1_HUMAN (1-585): 3.28e-51: 189: 26.37
+	Hs
		617108 PTPRG_HUMAN (33-527): 9.52e-62: 223: 17.05		GAB1_HUMAN (1-585): 3.28e-51: 189: 26.37
+	Hs
		660868 PTPRM_HUMAN (35-525): 2.5e-69: 245: 19.06		CNKR1_HUMAN (4-312): 1.98e-41: 161: 17.61
+	Dm
		665797 CSW_DROME (1-317): 7.21e-59: 212: 64.35		DOS_DROME (8-522): 1.95e-37: 150: 15.59