HitPredict

Interactor 1: PTN11 (Q06124)
Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1D) (PTP-1D) (Protein-tyrosine phosphatase 2C) (PTP-2C) (SH-PTP2) (SHP-2) (Shp2) (SH-PTP3)
Gene: PTPN11

Interactor 2: SIG10 (Q96LC7)
Sialic acid-binding Ig-like lectin 10 (Siglec-10) (Siglec-like protein 2)
Gene: SIGLEC10

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.50	0.533

Property	Details
Experiments	11733002, 11328818
Identification Methods	pull down, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 593 Hs			1 697
+	Mm
		719313 PTN11_MOUSE (1-593): 0: 580: 99.49		SIG10_MOUSE (13-697): 8.79e-120: 375: 56.71
+	Hs
		665940 PTN6_HUMAN (6-593): 0: 531: 55.27		SIG10_HUMAN (15-697): 4.22e-132: 407: 100.00
+	Hs
		986018 PTN11_HUMAN (1-593): 0: 581: 100.00		SIG11_HUMAN (12-697): 2.12e-110: 351: 69.53
+	Hs
		665942 PTN6_HUMAN (6-593): 0: 531: 55.27		SIG11_HUMAN (12-697): 2.12e-110: 351: 69.53
+	Hs
		177596 PTN11_HUMAN (1-593): 0: 581: 100.00		SIGL5_HUMAN (11-440): 8.2e-90: 292: 36.91
+	Hs
		177594 PTN6_HUMAN (6-593): 0: 531: 55.27		SIGL5_HUMAN (11-440): 8.2e-90: 292: 36.91
+	Hs
		985950 PTN11_HUMAN (1-593): 0: 581: 100.00		PTK7_HUMAN (250-528): 2.11e-35: 145: 17.81
+	Hs
		986060 PTN11_HUMAN (1-593): 0: 581: 100.00		SIGL7_HUMAN (262-696): 1.59e-26: 115: 17.04
+	Hs
		986062 PTN11_HUMAN (1-593): 0: 581: 100.00		SIGL9_HUMAN (278-697): 2.03e-23: 106: 20.00
+	Hs
		665883 PTN6_HUMAN (6-593): 0: 531: 55.27		PTK7_HUMAN (250-528): 2.11e-35: 145: 17.81
+	Hs
		616914 PTPRB_HUMAN (147-555): 2.35e-115: 379: 27.91		CNTN1_HUMAN (1-680): 4.63e-87: 296: 13.72
+	Hs
		590601 PTN6_HUMAN (6-593): 0: 531: 55.27		CD22_HUMAN (102-510): 7.23e-32: 134: 21.01
+	Hs
		589567 PTN11_HUMAN (1-593): 0: 581: 100.00		CD33_HUMAN (393-697): 1.93e-14: 77.3: 22.12
+	Mm
		665976 PTN6_MOUSE (6-583): 0: 530: 55.94		CD22_MOUSE (86-450): 4.58e-30: 128: 20.76
+	Hs
		665970 PTN6_HUMAN (6-593): 0: 531: 55.27		SIGL7_HUMAN (262-696): 1.59e-26: 115: 17.04
+	Hs
		665971 PTN6_HUMAN (6-593): 0: 531: 55.27		SIGL9_HUMAN (278-697): 2.03e-23: 106: 20.00
+	Hs
		589559 PTN6_HUMAN (6-593): 0: 531: 55.27		CD33_HUMAN (393-697): 1.93e-14: 77.3: 22.12
+	Hs
		616927 PTPRB_HUMAN (147-555): 2.35e-115: 379: 27.91		NRCAM_HUMAN (7-694): 8.46e-56: 208: 11.80
+	Dm
		1308480 Q9W4F5_DROME (191-560): 1.41e-112: 371: 29.38		Q9BN17_DROME (31-495): 3.23e-22: 104: 14.93
+	Hs
		663992 PTN4_HUMAN (143-535): 1.5e-113: 362: 30.46		ICAM5_HUMAN (217-475): 7.9e-11: 67.8: 27.55