HitPredict

Interactor 1: PTN11 (Q06124)
Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1D) (PTP-1D) (Protein-tyrosine phosphatase 2C) (PTP-2C) (SH-PTP2) (SHP-2) (Shp2) (SH-PTP3)
Gene: PTPN11

Interactor 2: ALK (Q9UM73)
ALK tyrosine kinase receptor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD antigen CD246)
Gene: ALK

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~Y_phosphatase
Common GO terms	GO:0032991 - protein-containing complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 593 Hs			1 1620
+	Hs
		666580 PTN11_HUMAN (1-593): 0: 581: 100.00		LTK_HUMAN (606-1458): 6.35e-175: 550: 53.24
+	Hs
		434178 PTN11_HUMAN (1-593): 0: 581: 100.00		RET_HUMAN (842-1477): 4.8e-137: 455: 23.56
+	Hs
		985960 PTN11_HUMAN (1-593): 0: 581: 100.00		ERBB4_HUMAN (882-1547): 2.9e-122: 418: 22.24
+	Hs
		601501 PTN11_HUMAN (1-593): 0: 581: 100.00		FGFR2_HUMAN (952-1433): 9.52e-123: 407: 25.24
+	Hs
		609260 PTN11_HUMAN (1-593): 0: 581: 100.00		FGFR3_HUMAN (952-1449): 6.42e-121: 401: 26.31
+	Hs
		445845 PTN11_HUMAN (1-593): 0: 581: 100.00		ROS1_HUMAN (1039-1461): 3.68e-112: 397: 37.75
+	Hs
		507959 PTN11_HUMAN (1-593): 0: 581: 100.00		FGFR1_HUMAN (952-1454): 2.04e-118: 395: 26.06
+	Mm
		719300 PTN11_MOUSE (1-593): 0: 580: 99.49		TIE2_MOUSE (954-1389): 3.85e-115: 394: 28.79
+	Hs
		972319 PTN11_HUMAN (1-593): 0: 581: 100.00		TIE2_HUMAN (954-1389): 7.66e-115: 393: 29.30
+	Hs
		411363 PTN11_HUMAN (1-593): 0: 581: 100.00		INSR_HUMAN (973-1436): 1.01e-112: 392: 34.25
+	Rn
		783510 PTN11_RAT (1-593): 0: 578: 98.99		T2CB11_RAT (973-1484): 1.47e-112: 392: 32.38
+	Hs
		435620 PTN11_HUMAN (1-593): 0: 581: 100.00		IGF1R_HUMAN (1037-1385): 8.86e-111: 386: 39.77
+	Hs
		985954 PTN11_HUMAN (1-593): 0: 581: 100.00		FAK2_HUMAN (1054-1518): 4.66e-109: 374: 27.45
+	Hs
		985963 PTN11_HUMAN (1-593): 0: 581: 100.00		NTRK2_HUMAN (1093-1375): 7.35e-64: 236: 41.44
+	Mm
		546284 PTN11_MOUSE (1-593): 0: 580: 99.49		NTRK2_MOUSE (1093-1379): 6.2e-64: 236: 41.22
+	Rn
		783507 PTN11_RAT (1-593): 0: 578: 98.99		NTRK2_RAT (1093-1375): 8.02e-64: 236: 41.44
+	Hs
		384697 PTN11_HUMAN (1-593): 0: 581: 100.00		NTRK1_HUMAN (1111-1392): 5.05e-62: 230: 42.07
+	Hs
		985962 PTN11_HUMAN (1-593): 0: 581: 100.00		NTRK3_HUMAN (1093-1375): 2.69e-59: 223: 39.03
+	Mm
		562607 PTN11_MOUSE (1-593): 0: 580: 99.49		FES_MOUSE (1101-1383): 3.21e-59: 222: 41.72
+	Hs
		384330 PTN6_HUMAN (6-593): 0: 531: 55.27		NTRK1_HUMAN (1111-1392): 5.05e-62: 230: 42.07