Interactor 1: PSME1 (Q06323)
Proteasome activator complex subunit 1 (11S regulator complex subunit alpha) (REG-alpha) (Activator of multicatalytic protease subunit 1) (Interferon gamma up-regulated I-5111 protein) (IGUP I-5111) (Proteasome activator 28 subunit alpha) (PA28a) (PA28alpha)
Gene: PSME1

Interactor 2: PSME2 (Q9UL46)
Proteasome activator complex subunit 2 (11S regulator complex subunit beta) (REG-beta) (Activator of multicatalytic protease subunit 2) (Proteasome activator 28 subunit beta) (PA28b) (PA28beta)
Gene: PSME2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.95 1.00 0.978

The method score is based on:

Property Details
Experiments 35271311, 9346951, 16189514, 32296183, 8663520, 33961781, 34349018, 37071682, 19017543, 9325261, unassigned1304
Identification Methods affinity chromatography technology, pull down, two hybrid, cross-linking study, anti tag coimmunoprecipitation, two hybrid array, validated two hybrid, two hybrid prey pooling approach, two hybrid pooling approach
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains PA28_alpha~PA28_alpha, PA28_alpha~PA28_beta, PA28_beta~PA28_beta
Common GO terms GO:0000502 - proteasome complex
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0008537 - proteasome activator complex
and 4 others

more...

Homologous interactions 4

Homologous interactions

Color coding for hit scores

1 249
Hs

1 239
+ Hs
+ Hs
+ Hs
+ Dm

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Last updated: 15 Jul 2024