HitPredict

Interactor 1: RING1 (Q06587)
E3 ubiquitin-protein ligase RING1 (EC 2.3.2.27) (Polycomb complex protein RING1) (RING finger protein 1) (RING-type E3 ubiquitin transferase RING1) (Really interesting new gene 1 protein)
Gene: RING1

Interactor 2: YAF2 (Q8IY57)
YY1-associated factor 2
Gene: YAF2

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.95	1.00	0.980

Property	Details
Experiments	21516116, 28514442, 27705803, 27684187, 32296183, 33961781, 22325352, 25416956, 24981860, unassigned1304
Identification Methods	two hybrid, affinity chromatography technology, validated two hybrid, two hybrid array, two hybrid prey pooling approach, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	RAWUL~YAF2_RYBP
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0045892 - negative regulation of DNA-templated transcription GO:0046872 - metal ion binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 406 Hs			1 180
+	Mm
		1307837 RING2_MOUSE (8-406): 2.94e-100: 303: 54.25		YAF2_MOUSE (1-180): 3.8e-76: 227: 91.67
+	Hs
		1222214 RING2_HUMAN (8-406): 4.9e-100: 302: 54.25		YAF2_HUMAN (1-180): 8.51e-73: 218: 100.00
+	Mm
		193411 RING1_MOUSE (1-406): 2.17e-118: 352: 96.55		RYBP_MOUSE (1-179): 3.52e-49: 160: 49.78
+	Hs
		987991 RING1_HUMAN (1-406): 2.01e-114: 342: 100.00		RYBP_HUMAN (1-179): 5.8e-49: 160: 49.78
+	Mm
		1208123 RING2_MOUSE (8-406): 2.94e-100: 303: 54.25		RYBP_MOUSE (1-179): 3.52e-49: 160: 49.78
+	Hs
		1233162 RING2_HUMAN (8-406): 4.9e-100: 302: 54.25		RYBP_HUMAN (1-179): 5.8e-49: 160: 49.78
+	Hs
		718000 BMI1_HUMAN (31-378): 4.06e-63: 207: 14.16		YAF2_HUMAN (1-180): 8.51e-73: 218: 100.00
+	Hs
		718409 PCGF2_HUMAN (31-377): 1.44e-41: 151: 14.37		YAF2_HUMAN (1-180): 8.51e-73: 218: 100.00
+	Hs
		1222219 PCGF6_HUMAN (31-157): 1.02e-40: 149: 23.08		YAF2_HUMAN (1-180): 8.51e-73: 218: 100.00
+	Hs
		718013 BMI1_HUMAN (31-378): 4.06e-63: 207: 14.16		RYBP_HUMAN (1-179): 5.8e-49: 160: 49.78
+	Hs
		1222217 PCGF1_HUMAN (25-133): 3.54e-40: 145: 25.00		YAF2_HUMAN (1-180): 8.51e-73: 218: 100.00
+	Hs
		1108516 PCGF3_HUMAN (34-224): 6.2e-39: 141: 17.53		YAF2_HUMAN (1-180): 8.51e-73: 218: 100.00
+	Dm
		1361718 RING1_DROME (1-159): 2.1e-47: 169: 74.84		Q9W215_DROME (1-133): 1.35e-51: 163: 51.13
+	Hs
		585013 RO52_HUMAN (33-392): 4.67e-43: 158: 13.14		RYBP_HUMAN (1-179): 5.8e-49: 160: 49.78
+	Hs
		718410 PCGF2_HUMAN (31-377): 1.44e-41: 151: 14.37		RYBP_HUMAN (1-179): 5.8e-49: 160: 49.78
+	Hs
		1233190 PCGF6_HUMAN (31-157): 1.02e-40: 149: 23.08		RYBP_HUMAN (1-179): 5.8e-49: 160: 49.78
+	Mm
		620789 PCGF2_MOUSE (31-345): 1.16e-40: 149: 13.93		RYBP_MOUSE (1-179): 3.52e-49: 160: 49.78
+	Mm
		1208119 PCGF1_MOUSE (25-149): 1.99e-40: 146: 23.44		RYBP_MOUSE (1-179): 3.52e-49: 160: 49.78
+	Hs
		1233178 PCGF1_HUMAN (25-133): 3.54e-40: 145: 25.00		RYBP_HUMAN (1-179): 5.8e-49: 160: 49.78
+	Mm
		1208122 PCGF6_MOUSE (31-157): 7.63e-39: 144: 23.08		RYBP_MOUSE (1-179): 3.52e-49: 160: 49.78