HitPredict

Interactor 1: FMR1 (Q06787)
Fragile X messenger ribonucleoprotein 1 (Fragile X messenger ribonucleoprotein) (FMRP) (Protein FMR-1)
Gene: FMR1

Interactor 2: PRC2C (Q9Y520)
Protein PRRC2C (BAT2 domain-containing protein 1) (HBV X-transactivated gene 2 protein) (HBV XAg-transactivated protein 2) (HLA-B-associated transcript 2-like 2) (Proline-rich and coiled-coil-containing protein 2C)
Gene: PRRC2C

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.70	0.60	0.650

Property	Details
Experiments	29395067, 26949739, 32525608
Identification Methods	proximity labelling technology, affinity chromatography technology, cross-linking study, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005829 - cytosol GO:0010494 - cytoplasmic stress granule GO:0016020 - membrane GO:0034063 - stress granule assembly
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 632 Hs			1 2896
+	Mm
		729462 FMR1_MOUSE (1-632): 0: 1063: 93.99		PRC2C_MOUSE (1-2896): 0: 713: 83.24
+	Mm
		1111989 Q8BPK8_MOUSE (1-357): 0: 688: 97.76		PRC2C_MOUSE (1-2896): 0: 713: 83.24
+	Hs
		843980 FXR1_HUMAN (1-334): 0: 604: 73.95		PRC2C_HUMAN (1-2896): 0: 771: 100.00
+	Mm
		1111986 FXR1_MOUSE (1-334): 0: 596: 73.65		PRC2C_MOUSE (1-2896): 0: 713: 83.24
+	Hs
		311804 FMR1_HUMAN (1-632): 0: 1106: 100.00		TACC2_HUMAN (62-2285): 2.28e-23: 111: 9.24
+	Hs
		820894 FMR1_HUMAN (1-632): 0: 1106: 100.00		PRC2A_HUMAN (1183-2870): 8.38e-21: 103: 8.16
+	Hs
		988930 FMR1_HUMAN (1-632): 0: 1106: 100.00		PRC2B_HUMAN (894-2896): 3.68e-13: 78.3: 6.73
+	Mm
		292190 FMR1_MOUSE (1-632): 0: 1063: 93.99		BSN_MOUSE (29-1686): 3.93e-18: 94.8: 8.16
+	Mm
		729583 FMR1_MOUSE (1-632): 0: 1063: 93.99		ANR17_MOUSE (1566-2453): 3.47e-14: 81.6: 15.34
+	Mm
		729608 FMR1_MOUSE (1-632): 0: 1063: 93.99		NCOR2_MOUSE (1109-2884): 1.02e-09: 66.7: 8.66
+	Mm
		729533 FMR1_MOUSE (1-632): 0: 1063: 93.99		PRC2A_MOUSE (2007-2896): 2.45e-09: 65.6: 8.30
+	Mm
		729531 FMR1_MOUSE (1-632): 0: 1063: 93.99		PRC2B_MOUSE (1566-2896): 4.65e-09: 64.4: 7.39
+	Mm
		292197 Q8BPK8_MOUSE (1-357): 0: 688: 97.76		BSN_MOUSE (29-1686): 3.93e-18: 94.8: 8.16
+	Mm
		1207085 Q8BPK8_MOUSE (1-357): 0: 688: 97.76		ANR17_MOUSE (1566-2453): 3.47e-14: 81.6: 15.34
+	Mm
		1207112 Q8BPK8_MOUSE (1-357): 0: 688: 97.76		NCOR2_MOUSE (1109-2884): 1.02e-09: 66.7: 8.66
+	Mm
		1186751 Q8BPK8_MOUSE (1-357): 0: 688: 97.76		PRC2A_MOUSE (2007-2896): 2.45e-09: 65.6: 8.30
+	Mm
		1186627 Q8BPK8_MOUSE (1-357): 0: 688: 97.76		PRC2B_MOUSE (1566-2896): 4.65e-09: 64.4: 7.39
+	Hs
		311796 FXR1_HUMAN (1-334): 0: 604: 73.95		TACC2_HUMAN (62-2285): 2.28e-23: 111: 9.24
+	Hs
		820851 FXR1_HUMAN (1-334): 0: 604: 73.95		PRC2A_HUMAN (1183-2870): 8.38e-21: 103: 8.16
+	Hs
		843719 FXR1_HUMAN (1-334): 0: 604: 73.95		PRC2B_HUMAN (894-2896): 3.68e-13: 78.3: 6.73