HitPredict

Interactor 1: PRDX1 (Q06830)
Peroxiredoxin-1 (EC 1.11.1.24) (Natural killer cell-enhancing factor A) (NKEF-A) (Proliferation-associated gene protein) (PAG) (Thioredoxin peroxidase 2) (Thioredoxin-dependent peroxide reductase 2) (Thioredoxin-dependent peroxiredoxin 1)
Gene: PRDX1

Interactor 2: LRRK2 (Q5S007)
Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin)
Gene: LRRK2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	31046837, unassigned1853
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005615 - extracellular space GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006979 - response to oxidative stress GO:0070062 - extracellular exosome
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 199 Hs			1 2527
+	Hs
		1130800 V9HW12_HUMAN (1-198): 2.38e-103: 297: 77.78		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Hs
		685703 PRDX2_HUMAN (1-198): 2.38e-103: 297: 77.78		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Hs
		670963 PRDX3_HUMAN (2-197): 1.85e-98: 287: 62.76		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Hs
		1026699 PRDX4_HUMAN (4-197): 4.03e-95: 279: 69.59		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Hs
		1130809 V9HW63_HUMAN (4-197): 4.03e-95: 279: 69.59		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Hs
		1130816 V9HWC7_HUMAN (4-197): 5.84e-67: 206: 28.50		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Hs
		201232 PRDX3_HUMAN (2-197): 1.85e-98: 287: 62.76		M3K7_HUMAN (1869-2132): 8.36e-23: 107: 28.83
+	Hs
		201231 PRDX6_HUMAN (4-197): 5.84e-67: 206: 28.50		M3K7_HUMAN (1869-2132): 8.36e-23: 107: 28.83