HitPredict

Interactor 1: ZO1 (Q07157)
Tight junction protein ZO-1 (Tight junction protein 1) (Zona occludens protein 1) (Zonula occludens protein 1)
Gene: TJP1

Interactor 2: SH319 (Q5HYK7)
SH3 domain-containing protein 19 (ADAM-binding protein Eve-1) (EEN-binding protein) (EBP)
Gene: SH3D19

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Guanylate_kin~SH3_1, Guanylate_kin~SH3_2, PDZ~SH3_2, SH3_1~SH3_2, SH3_2~SH3_2, SH3_2~SH3_9
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1748 Hs			1 790
+	Hs
		990871 ZO1_HUMAN (1-1748): 0: 925: 100.00		DNMBP_HUMAN (492-785): 3.4e-16: 85.6: 17.22
+	Dm
		993206 Q9VHK4_DROME (14-1358): 1.93e-170: 556: 26.59		GRAP_DROME (498-720): 2.27e-21: 95.2: 22.22
+	Hs
		1126376 ZO2_HUMAN (391-610): 1e-09: 65.7: 17.98		SH319_HUMAN (1-790): 3.57e-99: 327: 100.00
+	Hs
		1232491 PALS1_HUMAN (272-806): 1.75e-82: 288: 15.67		SH3K1_HUMAN (477-670): 2.62e-10: 65.9: 14.72
+	Mm
		1113245 DLG4_MOUSE (1-112): 2.37e-27: 122: 29.92		SRBS2_MOUSE (634-788): 1.16e-31: 135: 29.45
+	Hs
		1020196 PTN13_HUMAN (20-492): 4.02e-23: 110: 16.63		SH3R3_HUMAN (418-723): 9.67e-28: 122: 17.33
+	Hs
		924466 DLG4_HUMAN (1-112): 2.58e-27: 122: 29.92		GRB2_HUMAN (498-718): 1.8e-24: 104: 20.27
+	Mm
		1141133 DLG4_MOUSE (1-112): 2.37e-27: 122: 29.92		GRB2_MOUSE (498-718): 2.72e-24: 103: 20.27
+	Hs
		557746 DLG5_HUMAN (262-508): 3.83e-17: 90.3: 21.43		NCK1_HUMAN (414-659): 8.08e-29: 120: 19.93
+	Mm
		223014 DLG4_MOUSE (1-112): 2.37e-27: 122: 29.92		NCK2_MOUSE (346-572): 9.48e-15: 79: 13.25
+	Mm
		1143451 DLG4_MOUSE (1-112): 2.37e-27: 122: 29.92		SH3K1_MOUSE (309-686): 3.68e-13: 75.1: 11.84
+	Mm
		1143326 DLG4_MOUSE (1-112): 2.37e-27: 122: 29.92		SRBS1_MOUSE (621-790): 2.33e-12: 72.9: 16.94
+	Mm
		1143413 DLG4_MOUSE (1-112): 2.37e-27: 122: 29.92		SH3R3_MOUSE (212-550): 2.44e-12: 72.6: 18.28
+	Hs
		209185 ZO2_HUMAN (391-610): 1e-09: 65.7: 17.98		NCK2_HUMAN (414-652): 5.41e-28: 118: 20.36
+	Dm
		113976 M9PB30_DROME (1108-1664): 5.31e-24: 113: 15.83		M9PB30_DROME (26-487): 1.75e-11: 70.6: 14.64
+	Hs
		235554 DLG5_HUMAN (262-508): 3.83e-17: 90.3: 21.43		VINEX_HUMAN (621-788): 1.29e-13: 76.7: 18.82
+	Hs
		1354510 ZO2_HUMAN (391-610): 1e-09: 65.7: 17.98		CD2AP_HUMAN (300-607): 3.02e-17: 88.2: 10.87
+	Hs
		1167833 ZO2_HUMAN (391-610): 1e-09: 65.7: 17.98		DNMBP_HUMAN (492-785): 3.4e-16: 85.6: 17.22
+	Hs
		1285211 ZO2_HUMAN (391-610): 1e-09: 65.7: 17.98		SH3K1_HUMAN (477-670): 2.62e-10: 65.9: 14.72
+	Hs
		1314994 ZO2_HUMAN (391-610): 1e-09: 65.7: 17.98		SRBS1_HUMAN (672-788): 2.98e-09: 62.8: 33.07