HitPredict

Interactor 1: ZO1 (Q07157)
Tight junction protein ZO-1 (Tight junction protein 1) (Zona occludens protein 1) (Zonula occludens protein 1)
Gene: TJP1

Interactor 2: CXD3 (Q8N144)
Gap junction delta-3 protein (Connexin-31.9) (Cx31.9) (Gap junction alpha-11 protein) (Gap junction chi-1 protein)
Gene: GJD3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.55	0.60	0.578

Property	Details
Experiments	12154091
Identification Methods	affinity chromatography technology, pull down, anti bait coimmunoprecipitation
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1748 Hs			1 294
+	Hs
		567025 ZO1_HUMAN (1-1748): 0: 925: 100.00		CXA1_HUMAN (1-265): 1.52e-131: 380: 32.99
+	Hs
		816573 ZO1_HUMAN (1-1748): 0: 925: 100.00		CXA8_HUMAN (1-224): 5.39e-119: 350: 40.59
+	Hs
		990963 ZO1_HUMAN (1-1748): 0: 925: 100.00		CXA3_HUMAN (1-269): 6.24e-113: 334: 37.54
+	Mm
		613304 ZO1_MOUSE (1-1748): 0: 874: 90.79		CXA1_MOUSE (1-265): 1.48e-132: 382: 33.68
+	Rn
		94331 F1M4A0_RAT (27-1748): 0: 866: 90.88		CXA1_RAT (1-265): 8.88e-133: 383: 33.68
+	Mm
		761849 ZO1_MOUSE (1-1748): 0: 874: 90.79		CXB6_MOUSE (3-236): 4.18e-117: 338: 35.12
+	Hs
		159154 CSKP_HUMAN (217-806): 6.5e-86: 305: 14.66		CXA1_HUMAN (1-265): 1.52e-131: 380: 32.99
+	Hs
		567101 MPP7_HUMAN (310-807): 3.29e-83: 287: 14.96		CXA1_HUMAN (1-265): 1.52e-131: 380: 32.99
+	Hs
		1132879 MPP7_HUMAN (310-807): 3.29e-83: 287: 14.96		CXD3_HUMAN (1-294): 1.36e-123: 356: 100.00
+	Hs
		567033 PTN13_HUMAN (20-492): 4.02e-23: 110: 16.63		CXA1_HUMAN (1-265): 1.52e-131: 380: 32.99
+	Rn
		435339 Q3ZB99_RAT (1086-1374): 1.62e-20: 101: 20.00		CXA1_RAT (1-265): 8.88e-133: 383: 33.68
+	Hs
		567187 DLG5_HUMAN (262-508): 3.83e-17: 90.3: 21.43		CXA1_HUMAN (1-265): 1.52e-131: 380: 32.99
+	Hs
		567035 DLG1_HUMAN (263-512): 3.61e-17: 90: 16.54		CXA1_HUMAN (1-265): 1.52e-131: 380: 32.99
+	Hs
		1020192 PTN13_HUMAN (20-492): 4.02e-23: 110: 16.63		CXD3_HUMAN (1-294): 1.36e-123: 356: 100.00
+	Hs
		1230293 DLG5_HUMAN (262-508): 3.83e-17: 90.3: 21.43		CXD3_HUMAN (1-294): 1.36e-123: 356: 100.00
+	Hs
		1021533 DLG1_HUMAN (263-512): 3.61e-17: 90: 16.54		CXD3_HUMAN (1-294): 1.36e-123: 356: 100.00
+	Hs
		661171 INADL_HUMAN (60-583): 5.65e-19: 96.5: 18.77		CXB2_HUMAN (3-224): 1.86e-112: 325: 35.40
+	Hs
		434831 DLG1_HUMAN (263-512): 3.61e-17: 90: 16.54		CXB1_HUMAN (3-230): 2.66e-106: 312: 37.83
+	Hs
		1021517 DLG1_HUMAN (263-512): 3.61e-17: 90: 16.54		CXB7_HUMAN (4-215): 1.18e-97: 288: 36.15
+	Mm
		222439 ZO2_MOUSE (172-572): 2.71e-15: 84.2: 16.94		CXD2_MOUSE (128-218): 1.55e-40: 145: 45.06