HitPredict

Interactor 1: ZO1 (Q07157)
Tight junction protein ZO-1 (Tight junction protein 1) (Zona occludens protein 1) (Zonula occludens protein 1)
Gene: TJP1

Interactor 2: ZO2 (Q9UDY2)
Tight junction protein ZO-2 (Tight junction protein 2) (Zona occludens protein 2) (Zonula occludens protein 2)
Gene: TJP2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.89 1.00 0.947

The method score is based on:

Property Details
Experiments 10575001, 9792688, 34079125, 35271311, 10026224, 24255178
Identification Methods affinity chromatography technology, proximity labelling technology, pull down, anti tag coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains Guanylate_kin~Guanylate_kin, Guanylate_kin~PDZ, Guanylate_kin~SH3_2, PDZ~PDZ, PDZ~SH3_2, SH3_2~SH3_2
Common GO terms GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0005912 - adherens junction
GO:0005923 - bicellular tight junction
GO:0035633 - maintenance of blood-brain barrier
and 7 others

more...
Homologous interactions 17

Homologous interactions

Color coding for hit scores

1 1748
Hs

1 1190
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024