HitPredict

Interactor 1: KHDR1 (Q07666)
KH domain-containing, RNA-binding, signal transduction-associated protein 1 (GAP-associated tyrosine phosphoprotein p62) (Src-associated in mitosis 68 kDa protein) (Sam68) (p21 Ras GTPase-activating protein-associated p62) (p68)
Gene: KHDRBS1

Interactor 2: YTDC1 (Q96MU7)
YTH domain-containing protein 1 (Splicing factor YT521) (YT521-B)
Gene: YTHDC1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.614

Property	Details
Experiments	10564280, unassigned1973
Identification Methods	affinity chromatography technology, two hybrid, two hybrid fragment pooling approach
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000381 - regulation of alternative mRNA splicing, via spliceosome GO:0003723 - RNA binding GO:0003729 - mRNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm and 1 others more... GO:0007283 - spermatogenesis
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 443 Hs			1 727
+	Hs
		1139254 KHDR2_HUMAN (99-443): 5.18e-130: 381: 60.62		YTDC1_HUMAN (1-673): 0: 567: 100.00
+	Hs
		267537 KHDR3_HUMAN (100-443): 1.37e-128: 377: 56.46		YTDC1_HUMAN (1-673): 0: 567: 100.00
+	Rn
		1337543 KHDR3_RAT (100-443): 1.79e-130: 381: 56.18		YTDC1_RAT (1-673): 0: 553: 91.23
+	Hs
		1192358 QKI_HUMAN (93-367): 1.56e-92: 284: 33.89		YTHD3_HUMAN (300-503): 4.24e-83: 276: 22.48
+	Hs
		1299676 QKI_HUMAN (93-367): 1.56e-92: 284: 33.89		YTHD1_HUMAN (300-521): 7.77e-81: 270: 22.55
+	Hs
		1075682 SF01_HUMAN (82-301): 6.63e-54: 192: 21.33		YTHD3_HUMAN (300-503): 4.24e-83: 276: 22.48
+	Hs
		1075744 SF01_HUMAN (82-301): 6.63e-54: 192: 21.33		YTHD1_HUMAN (300-521): 7.77e-81: 270: 22.55