HitPredict

Interactor 1: KHDR1 (Q07666)
KH domain-containing, RNA-binding, signal transduction-associated protein 1 (GAP-associated tyrosine phosphoprotein p62) (Src-associated in mitosis 68 kDa protein) (Sam68) (p21 Ras GTPase-activating protein-associated p62) (p68)
Gene: KHDRBS1

Interactor 2: CD2AP (Q9Y5K6)
CD2-associated protein (Adapter protein CMS) (Cas ligand with multiple SH3 domains)
Gene: CD2AP

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.49	0.60	0.545

Property	Details
Experiments	22745667, unassigned1973
Identification Methods	unspecified method, two hybrid fragment pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0017124 - SH3 domain binding GO:0050852 - T cell receptor signaling pathway
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 443 Hs			1 639
+	Hs
		991842 KHDR1_HUMAN (1-443): 3.7e-177: 504: 100.00		SH3K1_HUMAN (1-638): 3.71e-91: 297: 32.43
+	Hs
		209037 KHDR1_HUMAN (1-443): 3.7e-177: 504: 100.00		NCK2_HUMAN (2-361): 2.2e-59: 205: 16.17
+	Hs
		275187 KHDR1_HUMAN (1-443): 3.7e-177: 504: 100.00		GRAP2_HUMAN (2-329): 1.68e-45: 166: 12.83
+	Mm
		1141126 KHDR1_MOUSE (1-443): 0: 514: 94.36		GRB2_MOUSE (112-328): 1.43e-40: 149: 18.27
+	Hs
		924509 KHDR1_HUMAN (1-443): 3.7e-177: 504: 100.00		GRB2_HUMAN (112-328): 1.9e-40: 148: 18.27
+	Mm
		1141333 KHDR1_MOUSE (1-443): 0: 514: 94.36		NCK1_MOUSE (113-378): 6.4e-21: 97.3: 14.24
+	Hs
		557667 KHDR1_HUMAN (1-443): 3.7e-177: 504: 100.00		NCK1_HUMAN (113-378): 9.79e-21: 96.5: 14.24
+	Hs
		991805 KHDR1_HUMAN (1-443): 3.7e-177: 504: 100.00		DNMBP_HUMAN (113-602): 4.85e-17: 87.7: 15.23
+	Hs
		991902 KHDR1_HUMAN (1-443): 3.7e-177: 504: 100.00		ITSN2_HUMAN (1-63): 2.7e-12: 72.2: 34.92
+	Hs
		991778 KHDR1_HUMAN (1-443): 3.7e-177: 504: 100.00		ITSN1_HUMAN (1-55): 3.97e-11: 68.8: 43.64
+	Hs
		275201 KHDR2_HUMAN (99-443): 5.18e-130: 381: 60.62		GRAP2_HUMAN (2-329): 1.68e-45: 166: 12.83
+	Mm
		1141173 KHDR2_MOUSE (100-443): 8.36e-126: 370: 61.65		GRB2_MOUSE (112-328): 1.43e-40: 149: 18.27
+	Dm
		1360803 Q9W255_DROME (59-398): 6.04e-96: 295: 32.35		Q9VA36_DROME (4-395): 1.02e-46: 179: 26.40
+	Hs
		209060 SF01_HUMAN (82-301): 6.63e-54: 192: 21.33		NCK2_HUMAN (2-361): 2.2e-59: 205: 16.17