HitPredict

Interactor 1: BAX (Q07812)
Apoptosis regulator BAX (Bcl-2-like protein 4) (Bcl2-L-4)
Gene: BAX

Interactor 2: BAD (Q92934)
Bcl2-associated agonist of cell death (BAD) (Bcl-2-binding component 6) (Bcl-2-like protein 8) (Bcl2-L-8) (Bcl-xL/Bcl-2-associated death promoter) (Bcl2 antagonist of cell death)
Gene: BAD

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.54	1.00	0.737

The method score is based on:

Property	Details
Experiments	17274640, 19427863
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

The annotation score is based on:

Property	Details
Interacting Pfam domains	Bcl-2~Bcl-2_BAD
Common GO terms	GO:0001836 - release of cytochrome c from mitochondria GO:0005739 - mitochondrion GO:0005741 - mitochondrial outer membrane GO:0005829 - cytosol GO:0006915 - apoptotic process and 9 others more... GO:0006919 - activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0008289 - lipid binding GO:0008625 - extrinsic apoptotic signaling pathway via death domain receptors GO:0008630 - intrinsic apoptotic signaling pathway in response to DNA damage GO:0043065 - positive regulation of apoptotic process GO:0090200 - positive regulation of release of cytochrome c from mitochondria GO:0097191 - extrinsic apoptotic signaling pathway GO:0097192 - extrinsic apoptotic signaling pathway in absence of ligand GO:0097193 - intrinsic apoptotic signaling pathway
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1	192
Hs

1	168

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024