HitPredict

Interactor 1: BAX (Q07812)
Apoptosis regulator BAX (Bcl-2-like protein 4) (Bcl2-L-4)
Gene: BAX

Interactor 2: B2L10 (Q9HD36)
Bcl-2-like protein 10 (Bcl2-L-10) (Anti-apoptotic protein Boo) (Anti-apoptotic protein NrH) (Apoptosis regulator Bcl-B)
Gene: BCL2L10

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	1.00	0.847

The method score is based on:

Property	Details
Experiments	11278245, 33961781, 23235460
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

The annotation score is based on:

Property	Details
Interacting Pfam domains	Bcl-2~Bcl-2
Common GO terms	GO:0005739 - mitochondrion GO:0005741 - mitochondrial outer membrane GO:0005783 - endoplasmic reticulum GO:0005829 - cytosol GO:0006915 - apoptotic process and 6 others more... GO:0006919 - activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0008630 - intrinsic apoptotic signaling pathway in response to DNA damage GO:0016020 - membrane GO:0042803 - protein homodimerization activity GO:0046982 - protein heterodimerization activity GO:0097192 - extrinsic apoptotic signaling pathway in absence of ligand
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1	192
Hs

1	204

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024