HitPredict

Interactor 1: B2CL1 (Q07817)
Bcl-2-like protein 1 (Bcl2-L-1) (Apoptosis regulator Bcl-X)
Gene: BCL2L1

Interactor 2: BAK (Q16611)
Bcl-2 homologous antagonist/killer (Apoptosis regulator BAK) (Bcl-2-like protein 7) (Bcl2-L-7)
Gene: BAK1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.98 1.00 0.991

The method score is based on:

Property Details
Experiments 20836993, 12137781, 14596824, 15901672, 32064756, 33961781, 34098062, 10085290, 16189514, 29997244, 32296183, 26264872, 11175750, 19060904, 9027312, 23055042, unassigned1913, 31515488, unassigned1304, 22516262 and 2 others

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Identification Methods affinity chromatography technology, unspecified method, fluorescent resonance energy transfer, two hybrid, pull down, anti tag coimmunoprecipitation, two hybrid array, validated two hybrid, two hybrid prey pooling approach, scintillation proximity assay and 7 others

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Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains Bcl-2~Bcl-2, BH4~Bcl-2
Common GO terms GO:0001836 - release of cytochrome c from mitochondria
GO:0005739 - mitochondrion
GO:0005741 - mitochondrial outer membrane
GO:0005783 - endoplasmic reticulum
GO:0005829 - cytosol
and 10 others

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Homologous interactions 17

Homologous interactions

Color coding for hit scores

1 233
Hs

1 211
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Last updated: 15 Jul 2024