HitPredict

Interactor 1: KLC1 (Q07866)
Kinesin light chain 1 (KLC 1)
Gene: KLC1

Interactor 2: KIF5A (Q12840)
Kinesin heavy chain isoform 5A (Kinesin heavy chain neuron-specific 1) (Neuronal kinesin heavy chain) (NKHC)
Gene: KIF5A

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.85	0.60	0.718

Property	Details
Experiments	28514442, 9624122, 10491391, 33961781, 35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003774 - cytoskeletal motor activity GO:0005829 - cytosol GO:0005871 - kinesin complex GO:0005874 - microtubule GO:0007018 - microtubule-based movement and 2 others more... GO:0016020 - membrane GO:0019894 - kinesin binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 573 Hs			1 1032
+	Mm
		702846 Q8CD76_MOUSE (1-571): 1.06e-113: 353: 95.10		KIF5A_MOUSE (1-1032): 6.83e-152: 479: 97.29
+	Hs
		1017559 KLC2_HUMAN (5-571): 7.66e-95: 304: 68.43		KIF5A_HUMAN (1-1032): 1e-154: 487: 100.00
+	Hs
		231604 TMTC1_HUMAN (336-566): 2.77e-18: 90.8: 15.88		KIF1B_HUMAN (6-757): 2.78e-109: 376: 23.61
+	Ce
		712252 KLC_CAEEL (336-573): 3.18e-22: 102: 21.67		KINH_CAEEL (4-762): 1.74e-99: 334: 44.33
+	Mm
		1143114 Q8CD76_MOUSE (1-571): 1.06e-113: 353: 95.10		KINH_MOUSE (623-1016): 3.55e-14: 79.5: 10.00
+	Hs
		229856 KLC1_HUMAN (1-573): 2.46e-113: 350: 100.00		KIF5C_HUMAN (535-1017): 1.02e-14: 81: 9.20
+	Hs
		702891 KLC1_HUMAN (1-573): 2.46e-113: 350: 100.00		KINH_HUMAN (623-1018): 3.31e-14: 79.5: 10.45
+	Ce
		712255 Q21592_CAEEL (312-571): 4.83e-16: 83.1: 15.91		KINH_CAEEL (4-762): 1.74e-99: 334: 44.33
+	Hs
		229891 KLC4_HUMAN (5-571): 4.27e-99: 315: 68.53		KIF5C_HUMAN (535-1017): 1.02e-14: 81: 9.20
+	Hs
		702983 KLC4_HUMAN (5-571): 4.27e-99: 315: 68.53		KINH_HUMAN (623-1018): 3.31e-14: 79.5: 10.45
+	Hs
		229887 KLC2_HUMAN (5-571): 7.66e-95: 304: 68.43		KIF5C_HUMAN (535-1017): 1.02e-14: 81: 9.20
+	Hs
		702974 KLC2_HUMAN (5-571): 7.66e-95: 304: 68.43		KINH_HUMAN (623-1018): 3.31e-14: 79.5: 10.45
+	Rn
		881490 OGT1_RAT (31-384): 1.51e-29: 126: 13.08		KINH_RAT (623-1016): 2.52e-14: 79.9: 10.25
+	Hs
		253263 TMTC3_HUMAN (184-572): 1.42e-31: 132: 12.76		KI21B_HUMAN (250-858): 1.93e-10: 67.5: 10.51
+	Hs
		101750 F8W6L3_HUMAN (336-567): 8.43e-21: 98.2: 21.25		KINH_HUMAN (623-1018): 3.31e-14: 79.5: 10.45
+	Dm
		566087 KLC_DROME (325-567): 2.72e-19: 93.2: 19.59		KINH_DROME (551-1029): 8.98e-11: 68.3: 9.43
+	Mm
		660001 KLC3_MOUSE (356-571): 1.05e-13: 75.8: 17.41		KIF5C_MOUSE (477-1017): 2.72e-15: 83: 8.63
+	Hs
		229869 KLC3_HUMAN (376-571): 6.96e-13: 73.1: 17.65		KIF5C_HUMAN (535-1017): 1.02e-14: 81: 9.20
+	Hs
		702921 KLC3_HUMAN (376-571): 6.96e-13: 73.1: 17.65		KINH_HUMAN (623-1018): 3.31e-14: 79.5: 10.45
+	Dm
		115868 M9PGT5_DROME (212-499): 1.6e-14: 78.8: 16.01		KINH_DROME (551-1029): 8.98e-11: 68.3: 9.43