HitPredict

Interactor 1: PPARA (Q07869)
Peroxisome proliferator-activated receptor alpha (PPAR-alpha) (Nuclear receptor subfamily 1 group C member 1)
Gene: PPARA

Interactor 2: NCOA1 (Q15788)
Nuclear receptor coactivator 1 (NCoA-1) (EC 2.3.1.48) (Class E basic helix-loop-helix protein 74) (bHLHe74) (Protein Hin-2) (RIP160) (Renal carcinoma antigen NY-REN-52) (Steroid receptor coactivator 1) (SRC-1)
Gene: NCOA1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.91	1.00	0.955

Property	Details
Experiments	15888456, 12163133, 9407140, 9626662, 11698662, 10731636, 21775429
Identification Methods	pull down, fluorescent resonance energy transfer, two hybrid, x-ray crystallography, amplified luminescent proximity homogeneous assay
Interaction Type	direct interaction, association

Property	Details
Interacting Pfam domains	Hormone_recep~SRC-1
Common GO terms	GO:0000785 - chromatin GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0045893 - positive regulation of DNA-templated transcription GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 468 Hs			1 1441
+	Hs
		587177 RXRA_HUMAN (2-465): 5.7e-118: 355: 21.61		NCOA1_HUMAN (1-1441): 3.28e-155: 509: 100.00
+	Hs
		500491 THB_HUMAN (99-466): 3.59e-114: 345: 27.42		NCOA1_HUMAN (1-1441): 3.28e-155: 509: 100.00
+	Hs
		740535 PPARG_HUMAN (1-468): 2.71e-112: 342: 54.36		NCOA1_HUMAN (1-1441): 3.28e-155: 509: 100.00
+	Hs
		874384 NR1H2_HUMAN (19-464): 4.66e-112: 340: 22.93		NCOA1_HUMAN (1-1441): 3.28e-155: 509: 100.00
+	Hs
		975432 PPARD_HUMAN (61-468): 1.11e-110: 336: 66.02		NCOA1_HUMAN (1-1441): 3.28e-155: 509: 100.00
+	Hs
		126103 RXRA_HUMAN (2-465): 5.7e-118: 355: 21.61		BMAL1_HUMAN (1-539): 2.88e-105: 350: 16.16
+	Hs
		992458 PPARA_HUMAN (1-468): 1.4e-141: 415: 100.00		NCOA3_HUMAN (1-1343): 5.25e-75: 277: 24.33
+	Hs
		587212 RXRA_HUMAN (2-465): 5.7e-118: 355: 21.61		NCOA3_HUMAN (1-1343): 5.25e-75: 277: 24.33
+	Hs
		181498 RXRA_HUMAN (2-465): 5.7e-118: 355: 21.61		CLOCK_HUMAN (5-833): 1.42e-75: 271: 14.15
+	Hs
		500511 THB_HUMAN (99-466): 3.59e-114: 345: 27.42		NCOA3_HUMAN (1-1343): 5.25e-75: 277: 24.33
+	Hs
		740635 PPARG_HUMAN (1-468): 2.71e-112: 342: 54.36		NCOA3_HUMAN (1-1343): 5.25e-75: 277: 24.33
+	Hs
		874407 NR1H2_HUMAN (19-464): 4.66e-112: 340: 22.93		NCOA3_HUMAN (1-1343): 5.25e-75: 277: 24.33
+	Hs
		975487 PPARD_HUMAN (61-468): 1.11e-110: 336: 66.02		NCOA3_HUMAN (1-1343): 5.25e-75: 277: 24.33
+	Hs
		992420 PPARA_HUMAN (1-468): 1.4e-141: 415: 100.00		NCOA2_HUMAN (496-1439): 2.6e-11: 70.7: 9.43
+	Hs
		587173 RXRA_HUMAN (2-465): 5.7e-118: 355: 21.61		NCOA2_HUMAN (496-1439): 2.6e-11: 70.7: 9.43
+	Hs
		587195 RXRA_HUMAN (2-465): 5.7e-118: 355: 21.61		NPAS2_HUMAN (29-210): 2.08e-09: 64.3: 29.73
+	Hs
		500487 THB_HUMAN (99-466): 3.59e-114: 345: 27.42		NCOA2_HUMAN (496-1439): 2.6e-11: 70.7: 9.43
+	Mm
		740717 PPARG_MOUSE (1-468): 7.9e-112: 341: 53.94		NCOA2_MOUSE (496-1439): 7.26e-12: 72.6: 10.82
+	Hs
		740529 PPARG_HUMAN (1-468): 2.71e-112: 342: 54.36		NCOA2_HUMAN (496-1439): 2.6e-11: 70.7: 9.43
+	Hs
		975430 PPARD_HUMAN (61-468): 1.11e-110: 336: 66.02		NCOA2_HUMAN (496-1439): 2.6e-11: 70.7: 9.43