HitPredict

Interactor 1: PPARA (Q07869)
Peroxisome proliferator-activated receptor alpha (PPAR-alpha) (Nuclear receptor subfamily 1 group C member 1)
Gene: PPARA

Interactor 2: PRGC2 (Q86YN6)
Peroxisome proliferator-activated receptor gamma coactivator 1-beta (PGC-1-beta) (PPAR-gamma coactivator 1-beta) (PPARGC-1-beta) (PGC-1-related estrogen receptor alpha coactivator)
Gene: PPARGC1B

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	11733490
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 468 Hs			1 1023
+	Hs
		500495 THB_HUMAN (99-466): 3.59e-114: 345: 27.42		PRGC2_HUMAN (1-1023): 0: 1467: 100.00
+	Hs
		740551 PPARG_HUMAN (1-468): 2.71e-112: 342: 54.36		PRGC2_HUMAN (1-1023): 0: 1467: 100.00
+	Hs
		874389 NR1H2_HUMAN (19-464): 4.66e-112: 340: 22.93		PRGC2_HUMAN (1-1023): 0: 1467: 100.00
+	Hs
		369945 ESR1_HUMAN (11-464): 2.21e-107: 332: 18.30		PRGC2_HUMAN (1-1023): 0: 1467: 100.00
+	Hs
		914660 ERR3_HUMAN (3-465): 2.34e-105: 322: 21.55		PRGC2_HUMAN (1-1023): 0: 1467: 100.00
+	Hs
		782588 HNF4A_HUMAN (77-464): 1.45e-103: 318: 22.11		PRGC2_HUMAN (1-1023): 0: 1467: 100.00
+	Mm
		1257603 NR1H3_MOUSE (3-464): 6.58e-107: 326: 23.82		PRGC2_MOUSE (1-1023): 0: 1364: 78.38
+	Hs
		992454 PPARA_HUMAN (1-468): 1.4e-141: 415: 100.00		PRGC1_HUMAN (869-1022): 8.98e-57: 213: 47.40
+	Mm
		250727 PPARA_MOUSE (1-468): 7.27e-135: 398: 92.31		PRGC1_MOUSE (869-1022): 4.12e-58: 216: 46.10
+	Hs
		587203 RXRA_HUMAN (2-465): 5.7e-118: 355: 21.61		PRGC1_HUMAN (869-1022): 8.98e-57: 213: 47.40
+	Hs
		500508 THB_HUMAN (99-466): 3.59e-114: 345: 27.42		PRGC1_HUMAN (869-1022): 8.98e-57: 213: 47.40
+	Mm
		250732 PPARG_MOUSE (1-468): 7.9e-112: 341: 53.94		PRGC1_MOUSE (869-1022): 4.12e-58: 216: 46.10
+	Hs
		740612 PPARG_HUMAN (1-468): 2.71e-112: 342: 54.36		PRGC1_HUMAN (869-1022): 8.98e-57: 213: 47.40
+	Hs
		975478 PPARD_HUMAN (61-468): 1.11e-110: 336: 66.02		PRGC1_HUMAN (869-1022): 8.98e-57: 213: 47.40
+	Hs
		370621 ESR1_HUMAN (11-464): 2.21e-107: 332: 18.30		PRGC1_HUMAN (869-1022): 8.98e-57: 213: 47.40
+	Mm
		250749 NR1H3_MOUSE (3-464): 6.58e-107: 326: 23.82		PRGC1_MOUSE (869-1022): 4.12e-58: 216: 46.10
+	Mm
		250734 ERR3_MOUSE (3-465): 2.34e-105: 322: 21.55		PRGC1_MOUSE (869-1022): 4.12e-58: 216: 46.10
+	Mm
		250733 HNF4A_MOUSE (77-464): 1.2e-103: 319: 23.14		PRGC1_MOUSE (869-1022): 4.12e-58: 216: 46.10
+	Hs
		914678 ERR3_HUMAN (3-465): 2.34e-105: 322: 21.55		PRGC1_HUMAN (869-1022): 8.98e-57: 213: 47.40
+	Hs
		500377 RARB_HUMAN (31-466): 6.79e-105: 321: 26.74		PRGC1_HUMAN (869-1022): 8.98e-57: 213: 47.40