HitPredict

Interactor 1: SOS1 (Q07889)
Son of sevenless homolog 1 (SOS-1)
Gene: SOS1

Interactor 2: SPD2A (Q5TCZ1)
SH3 and PX domain-containing protein 2A (Adapter protein TKS5) (Five SH3 domain-containing protein) (SH3 multiple domains protein 1) (Tyrosine kinase substrate with five SH3 domains)
Gene: SH3PXD2A

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.55	1.00	0.747

Property	Details
Experiments	19464300
Identification Methods	peptide array, pull down, isothermal titration calorimetry
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PH~PX, PH~SH3_1, RhoGEF~SH3_1
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 1333 Hs			1 1133
+	Hs
		992477 SOS1_HUMAN (1-1333): 0: 991: 100.00		ITSN1_HUMAN (765-1133): 1.87e-22: 106: 11.47
+	Hs
		557668 SOS1_HUMAN (1-1333): 0: 991: 100.00		NCK1_HUMAN (272-569): 1.62e-23: 105: 14.64
+	Hs
		209038 SOS1_HUMAN (1-1333): 0: 991: 100.00		NCK2_HUMAN (813-1029): 7.64e-17: 85.8: 18.65
+	Hs
		992496 SOS1_HUMAN (1-1333): 0: 991: 100.00		ITSN2_HUMAN (58-295): 4.7e-15: 82.9: 11.77
+	Hs
		992505 SOS1_HUMAN (1-1333): 0: 991: 100.00		CD2AP_HUMAN (126-272): 6.38e-12: 71.7: 17.33
+	Hs
		992489 SOS1_HUMAN (1-1333): 0: 991: 100.00		SH3K1_HUMAN (270-877): 2.48e-09: 63.6: 11.75
+	Hs
		992508 SOS2_HUMAN (1-1332): 0: 855: 68.03		ITSN1_HUMAN (765-1133): 1.87e-22: 106: 11.47
+	Hs
		557669 SOS2_HUMAN (1-1332): 0: 855: 68.03		NCK1_HUMAN (272-569): 1.62e-23: 105: 14.64
+	Hs
		992521 SOS2_HUMAN (1-1332): 0: 855: 68.03		ITSN2_HUMAN (58-295): 4.7e-15: 82.9: 11.77
+	Hs
		992527 SOS2_HUMAN (1-1332): 0: 855: 68.03		CD2AP_HUMAN (126-272): 6.38e-12: 71.7: 17.33
+	Hs
		1136521 RGPS2_HUMAN (774-1100): 6.56e-79: 274: 23.67		SPD2A_HUMAN (1-1133): 5.76e-173: 541: 100.00
+	Hs
		1078876 PREX1_HUMAN (194-567): 2.78e-94: 337: 21.98		ITSN1_HUMAN (765-1133): 1.87e-22: 106: 11.47
+	Hs
		557683 RPGF1_HUMAN (571-1032): 8.27e-91: 320: 23.63		NCK1_HUMAN (272-569): 1.62e-23: 105: 14.64
+	Hs
		1203939 RGPS2_HUMAN (774-1100): 6.56e-79: 274: 23.67		SH3R3_HUMAN (384-1130): 4.05e-32: 137: 11.21
+	Hs
		557756 RPGF5_HUMAN (522-1018): 7.32e-85: 291: 16.12		NCK1_HUMAN (272-569): 1.62e-23: 105: 14.64
+	Hs
		156402 RGRF2_HUMAN (360-991): 7.8e-85: 305: 17.89		DNMBP_HUMAN (790-1131): 3.26e-09: 63.6: 11.77
+	Hs
		279897 TRIO_HUMAN (101-691): 1.18e-59: 229: 12.83		ITSN2_HUMAN (58-295): 4.7e-15: 82.9: 11.77
+	Hs
		279865 TRIO_HUMAN (101-691): 1.18e-59: 229: 12.83		ARHG7_HUMAN (744-985): 6.08e-10: 65.5: 14.62
+	Hs
		557709 RGPS1_HUMAN (774-945): 3.81e-23: 107: 31.43		NCK1_HUMAN (272-569): 1.62e-23: 105: 14.64