HitPredict

Interactor 1: SOS1 (Q07889)
Son of sevenless homolog 1 (SOS-1)
Gene: SOS1

Interactor 2: SRBS1 (Q9BX66)
Sorbin and SH3 domain-containing protein 1 (Ponsin) (SH3 domain protein 5) (SH3P12) (c-Cbl-associated protein) (CAP)
Gene: SORBS1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	17548467
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~SH3_1, PH~SH3_9, RhoGEF~SH3_1, RhoGEF~SH3_9
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0008286 - insulin receptor signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1333 Hs			1 1292
+	Hs
		992476 SOS1_HUMAN (1-1333): 0: 991: 100.00		SPTN1_HUMAN (304-902): 8.17e-59: 225: 13.39
+	Hs
		557668 SOS1_HUMAN (1-1333): 0: 991: 100.00		NCK1_HUMAN (708-1005): 1.37e-49: 182: 18.27
+	Hs
		209038 SOS1_HUMAN (1-1333): 0: 991: 100.00		NCK2_HUMAN (767-1019): 1.85e-42: 162: 16.23
+	Mm
		1143290 SOS1_MOUSE (1-1333): 0: 957: 96.47		PLCG1_MOUSE (394-868): 2.19e-42: 171: 12.47
+	Hs
		992477 SOS1_HUMAN (1-1333): 0: 991: 100.00		ITSN1_HUMAN (273-858): 7.03e-15: 82.5: 10.91
+	Hs
		992496 SOS1_HUMAN (1-1333): 0: 991: 100.00		ITSN2_HUMAN (1079-1290): 3.39e-12: 73.7: 14.49
+	Hs
		557669 SOS2_HUMAN (1-1332): 0: 855: 68.03		NCK1_HUMAN (708-1005): 1.37e-49: 182: 18.27
+	Hs
		992508 SOS2_HUMAN (1-1332): 0: 855: 68.03		ITSN1_HUMAN (273-858): 7.03e-15: 82.5: 10.91
+	Hs
		992521 SOS2_HUMAN (1-1332): 0: 855: 68.03		ITSN2_HUMAN (1079-1290): 3.39e-12: 73.7: 14.49
+	Mm
		57854 KALRN_MOUSE (8-594): 7.63e-64: 242: 13.53		SRBS1_MOUSE (1-1292): 3.51e-71: 263: 20.24
+	Hs
		557683 RPGF1_HUMAN (571-1032): 8.27e-91: 320: 23.63		NCK1_HUMAN (708-1005): 1.37e-49: 182: 18.27
+	Hs
		557756 RPGF5_HUMAN (522-1018): 7.32e-85: 291: 16.12		NCK1_HUMAN (708-1005): 1.37e-49: 182: 18.27
+	Hs
		224714 KALRN_HUMAN (8-625): 2.16e-64: 244: 12.85		SPTN1_HUMAN (304-902): 8.17e-59: 225: 13.39
+	Mm
		57809 KALRN_MOUSE (8-594): 7.63e-64: 242: 13.53		B9EKJ1_MOUSE (304-921): 5.86e-58: 223: 13.46
+	Mm
		57827 KALRN_MOUSE (8-594): 7.63e-64: 242: 13.53		SPTN1_MOUSE (304-921): 8.47e-58: 222: 13.46
+	Hs
		1078876 PREX1_HUMAN (194-567): 2.78e-94: 337: 21.98		ITSN1_HUMAN (273-858): 7.03e-15: 82.5: 10.91
+	Hs
		156402 RGRF2_HUMAN (360-991): 7.8e-85: 305: 17.89		DNMBP_HUMAN (796-1253): 2.23e-17: 90.7: 14.23
+	Hs
		1203939 RGPS2_HUMAN (774-1100): 6.56e-79: 274: 23.67		SH3R3_HUMAN (407-924): 1.49e-12: 74.3: 10.82
+	Hs
		279897 TRIO_HUMAN (101-691): 1.18e-59: 229: 12.83		ITSN2_HUMAN (1079-1290): 3.39e-12: 73.7: 14.49
+	Mm
		1143293 RGPS2_MOUSE (774-1023): 3.11e-23: 108: 27.17		PLCG1_MOUSE (394-868): 2.19e-42: 171: 12.47