HitPredict

Interactor 1: SOS1 (Q07889)
Son of sevenless homolog 1 (SOS-1)
Gene: SOS1

Interactor 2: ES8L2 (Q9H6S3)
Epidermal growth factor receptor kinase substrate 8-like protein 2 (EPS8-like protein 2) (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-related protein 2)
Gene: EPS8L2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	14565974
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~SH3_1, RhoGEF~SH3_1
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1333 Hs			1 715
+	Hs
		992474 SOS1_HUMAN (1-1333): 0: 991: 100.00		EPS8_HUMAN (2-715): 0: 745: 39.73
+	Mm
		995945 SOS1_MOUSE (1-1333): 0: 957: 96.47		EPS8_MOUSE (2-715): 0: 743: 38.42
+	Hs
		992486 SOS1_HUMAN (1-1333): 0: 991: 100.00		ES8L1_HUMAN (19-713): 0: 653: 38.16
+	Hs
		412150 SOS1_HUMAN (1-1333): 0: 991: 100.00		FYN_HUMAN (431-709): 8.42e-70: 239: 14.94
+	Hs
		522934 SOS1_HUMAN (1-1333): 0: 991: 100.00		SRC_HUMAN (425-709): 1.22e-68: 236: 14.04
+	Hs
		442816 SOS1_HUMAN (1-1333): 0: 991: 100.00		HCK_HUMAN (430-715): 6.22e-66: 228: 13.09
+	Hs
		411690 SOS1_HUMAN (1-1333): 0: 991: 100.00		LCK_HUMAN (416-715): 1.35e-60: 213: 12.79
+	Hs
		412151 SOS2_HUMAN (1-1332): 0: 855: 68.03		FYN_HUMAN (431-709): 8.42e-70: 239: 14.94
+	Hs
		522935 SOS2_HUMAN (1-1332): 0: 855: 68.03		SRC_HUMAN (425-709): 1.22e-68: 236: 14.04
+	Hs
		209038 SOS1_HUMAN (1-1333): 0: 991: 100.00		NCK2_HUMAN (492-556): 5.48e-20: 94.5: 30.77
+	Hs
		557668 SOS1_HUMAN (1-1333): 0: 991: 100.00		NCK1_HUMAN (492-556): 3.45e-16: 83: 27.69
+	Hs
		557669 SOS2_HUMAN (1-1332): 0: 855: 68.03		NCK1_HUMAN (492-556): 3.45e-16: 83: 27.69
+	Dm
		644374 SOS_DROME (8-1305): 0: 692: 42.34		SRC42_DROME (432-715): 3.38e-59: 210: 14.92
+	Hs
		522974 RGRF1_HUMAN (10-651): 1.6e-97: 343: 14.18		SRC_HUMAN (425-709): 1.22e-68: 236: 14.04
+	Hs
		412185 RPGF1_HUMAN (571-1032): 8.27e-91: 320: 23.63		FYN_HUMAN (431-709): 8.42e-70: 239: 14.94
+	Hs
		522972 RPGF1_HUMAN (571-1032): 8.27e-91: 320: 23.63		SRC_HUMAN (425-709): 1.22e-68: 236: 14.04
+	Hs
		442826 RPGF1_HUMAN (571-1032): 8.27e-91: 320: 23.63		HCK_HUMAN (430-715): 6.22e-66: 228: 13.09
+	Hs
		411580 VAV_HUMAN (134-691): 1.71e-76: 274: 14.41		LCK_HUMAN (416-715): 1.35e-60: 213: 12.79
+	Hs
		557683 RPGF1_HUMAN (571-1032): 8.27e-91: 320: 23.63		NCK1_HUMAN (492-556): 3.45e-16: 83: 27.69
+	Hs
		557756 RPGF5_HUMAN (522-1018): 7.32e-85: 291: 16.12		NCK1_HUMAN (492-556): 3.45e-16: 83: 27.69