HitPredict

Interactor 1: SOS1 (Q07889)
Son of sevenless homolog 1 (SOS-1)
Gene: SOS1

Interactor 2: ITSN2 (Q9NZM3)
Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein)
Gene: ITSN2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.62 1.00 0.791

The method score is based on:

Property Details
Experiments 20936779, 22558309
Identification Methods two hybrid, two hybrid pooling approach
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains PH~RhoGEF, PH~SH3_1, PH~SH3_9, RasGEF_N~RhoGEF, PH_13~RhoGEF, RhoGEF~RhoGEF, RhoGEF~SH3_1, RhoGEF~SH3_9
Common GO terms GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005886 - plasma membrane
Homologous interactions 16

Homologous interactions

Color coding for hit scores

1 1333
Hs

1 1697
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024