HitPredict

Interactor 1: SOS2 (Q07890)
Son of sevenless homolog 2 (SOS-2)
Gene: SOS2

Interactor 2: CD2AP (Q9Y5K6)
CD2-associated protein (Adapter protein CMS) (Cas ligand with multiple SH3 domains)
Gene: CD2AP

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	14679214
Identification Methods	pull down
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~SH3_1, PH~SH3_9, RhoGEF~SH3_1, RhoGEF~SH3_9
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1332 Hs			1 639
+	Hs
		992505 SOS1_HUMAN (1-1330): 0: 913: 67.29		CD2AP_HUMAN (1-639): 9.29e-139: 420: 100.00
+	Hs
		992489 SOS1_HUMAN (1-1330): 0: 913: 67.29		SH3K1_HUMAN (1-638): 3.71e-91: 297: 32.43
+	Hs
		275188 SOS2_HUMAN (1-1332): 0: 962: 100.00		GRAP2_HUMAN (2-329): 1.68e-45: 166: 12.83
+	Hs
		209038 SOS1_HUMAN (1-1330): 0: 913: 67.29		NCK2_HUMAN (2-361): 2.2e-59: 205: 16.17
+	Hs
		924512 SOS2_HUMAN (1-1332): 0: 962: 100.00		GRB2_HUMAN (112-328): 1.9e-40: 148: 18.27
+	Mm
		970654 SOS2_MOUSE (1-1332): 0: 959: 94.97		GRB2_MOUSE (112-328): 1.43e-40: 149: 18.27
+	Hs
		924511 SOS1_HUMAN (1-1330): 0: 913: 67.29		GRB2_HUMAN (112-328): 1.9e-40: 148: 18.27
+	Hs
		557669 SOS2_HUMAN (1-1332): 0: 962: 100.00		NCK1_HUMAN (113-378): 9.79e-21: 96.5: 14.24
+	Mm
		1141134 SOS1_MOUSE (1-1330): 0: 905: 67.34		GRB2_MOUSE (112-328): 1.43e-40: 149: 18.27
+	Hs
		992521 SOS2_HUMAN (1-1332): 0: 962: 100.00		ITSN2_HUMAN (1-63): 2.7e-12: 72.2: 34.92
+	Hs
		992508 SOS2_HUMAN (1-1332): 0: 962: 100.00		ITSN1_HUMAN (1-55): 3.97e-11: 68.8: 43.64
+	Hs
		557668 SOS1_HUMAN (1-1330): 0: 913: 67.29		NCK1_HUMAN (113-378): 9.79e-21: 96.5: 14.24
+	Hs
		992496 SOS1_HUMAN (1-1330): 0: 913: 67.29		ITSN2_HUMAN (1-63): 2.7e-12: 72.2: 34.92
+	Hs
		992477 SOS1_HUMAN (1-1330): 0: 913: 67.29		ITSN1_HUMAN (1-55): 3.97e-11: 68.8: 43.64
+	Hs
		200775 ARHG9_HUMAN (135-563): 4.02e-91: 306: 19.27		ARHG6_HUMAN (52-634): 3.49e-68: 239: 13.68
+	Hs
		924558 RPGF1_HUMAN (571-1020): 8.77e-96: 334: 25.99		GRB2_HUMAN (112-328): 1.9e-40: 148: 18.27
+	Mm
		1141157 Q91ZZ2_MOUSE (571-1020): 6.75e-95: 332: 25.77		GRB2_MOUSE (112-328): 1.43e-40: 149: 18.27
+	Hs
		557763 ARHG2_HUMAN (30-849): 9.08e-97: 335: 11.63		NCK1_HUMAN (113-378): 9.79e-21: 96.5: 14.24
+	Hs
		557683 RPGF1_HUMAN (571-1020): 8.77e-96: 334: 25.99		NCK1_HUMAN (113-378): 9.79e-21: 96.5: 14.24
+	Hs
		156402 RGRF2_HUMAN (562-1020): 4.4e-89: 317: 22.97		DNMBP_HUMAN (113-602): 4.85e-17: 87.7: 15.23