HitPredict

Interactor 1: ACK1 (Q07912)
Activated CDC42 kinase 1 (ACK-1) (EC 2.7.10.2) (EC 2.7.11.1) (Tyrosine kinase non-receptor protein 2)
Gene: TNK2

Interactor 2: LCP2 (Q13094)
Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76)
Gene: LCP2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	28188290
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1038 Hs			1 533
+	Mm
		222842 ACK1_MOUSE (1-1038): 0: 793: 92.70		LCP2_MOUSE (1-531): 8.21e-72: 240: 80.98
+	Hs
		1024132 ERBB4_HUMAN (84-754): 3.34e-128: 423: 24.17		LCP2_HUMAN (1-533): 1.59e-78: 258: 100.00
+	Hs
		522951 SRC_HUMAN (1-400): 3.99e-127: 399: 31.42		LCP2_HUMAN (1-533): 1.59e-78: 258: 100.00
+	Hs
		412165 FYN_HUMAN (1-400): 2.52e-126: 397: 30.18		LCP2_HUMAN (1-533): 1.59e-78: 258: 100.00
+	Mm
		763395 FYN_MOUSE (1-400): 4.06e-126: 396: 30.18		LCP2_MOUSE (1-531): 8.21e-72: 240: 80.98
+	Hs
		1070974 ERBB4_HUMAN (84-754): 3.34e-128: 423: 24.17		TENS2_HUMAN (79-512): 3.43e-30: 127: 17.32
+	Hs
		983624 FAK1_HUMAN (6-692): 3.3e-131: 425: 21.01		TENS3_HUMAN (83-512): 1.87e-28: 122: 12.50
+	Hs
		1070975 ERBB4_HUMAN (84-754): 3.34e-128: 423: 24.17		TENS3_HUMAN (83-512): 1.87e-28: 122: 12.50
+	Hs
		337335 ABL1_HUMAN (1-955): 4.84e-144: 462: 19.03		MUC1_HUMAN (87-469): 7.93e-15: 79.7: 9.92
+	Mm
		763411 FYN_MOUSE (1-400): 4.06e-126: 396: 30.18		CLNK_MOUSE (150-528): 6.78e-37: 143: 28.57
+	Mm
		536209 FGR_MOUSE (1-401): 1.3e-125: 394: 30.60		CLNK_MOUSE (150-528): 6.78e-37: 143: 28.57
+	Rn
		94037 Q9QX70_RAT (83-611): 5.81e-119: 396: 27.37		F1LN91_RAT (103-512): 2.27e-33: 137: 12.39
+	Hs
		872663 EPHA4_HUMAN (84-486): 5.91e-125: 407: 23.98		TENS3_HUMAN (83-512): 1.87e-28: 122: 12.50
+	Hs
		1071015 ERBB4_HUMAN (84-754): 3.34e-128: 423: 24.17		TENS1_HUMAN (85-512): 1.44e-22: 104: 14.61
+	Hs
		1070981 ERBB4_HUMAN (84-754): 3.34e-128: 423: 24.17		TENS4_HUMAN (98-512): 8.78e-21: 98.2: 14.12
+	Hs
		523025 SRC_HUMAN (1-400): 3.99e-127: 399: 31.42		TENS3_HUMAN (83-512): 1.87e-28: 122: 12.50
+	Hs
		554307 ERBB4_HUMAN (84-754): 3.34e-128: 423: 24.17		MUC1_HUMAN (87-469): 7.93e-15: 79.7: 9.92
+	Hs
		203198 LCK_HUMAN (1-398): 8.72e-125: 391: 30.08		SYNJ1_HUMAN (10-466): 1.18e-22: 104: 11.71
+	Hs
		522749 SRC_HUMAN (1-400): 3.99e-127: 399: 31.42		MUC1_HUMAN (87-469): 7.93e-15: 79.7: 9.92
+	Hs
		412433 FYN_HUMAN (1-400): 2.52e-126: 397: 30.18		MYO16_HUMAN (111-438): 6.65e-11: 67.4: 12.90