HitPredict

Interactor 1: ACK1 (Q07912)
Activated CDC42 kinase 1 (ACK-1) (EC 2.7.10.2) (EC 2.7.11.1) (Tyrosine kinase non-receptor protein 2)
Gene: TNK2

Interactor 2: RGF1C (Q8N431)
Ras-GEF domain-containing family member 1C
Gene: RASGEF1C

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.34	0.60	0.457

Property	Details
Experiments	16169070
Identification Methods	two hybrid pooling approach
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1038 Hs			1 466
+	Hs
		337446 ABL1_HUMAN (1-955): 4.84e-144: 462: 19.03		SOS1_HUMAN (4-464): 6e-117: 374: 18.18
+	Hs
		337447 ABL1_HUMAN (1-955): 4.84e-144: 462: 19.03		SOS2_HUMAN (2-464): 1.72e-114: 367: 17.47
+	Hs
		983594 FAK1_HUMAN (6-692): 3.3e-131: 425: 21.01		SOS1_HUMAN (4-464): 6e-117: 374: 18.18
+	Mm
		337633 ABL1_MOUSE (1-955): 1.72e-152: 484: 20.27		Q8C5V7_MOUSE (3-459): 7.01e-100: 314: 19.57
+	Hs
		337471 ABL1_HUMAN (1-955): 4.84e-144: 462: 19.03		RPGF1_HUMAN (3-459): 8.74e-98: 318: 19.57
+	Hs
		522934 SRC_HUMAN (1-400): 3.99e-127: 399: 31.42		SOS1_HUMAN (4-464): 6e-117: 374: 18.18
+	Hs
		412150 FYN_HUMAN (1-400): 2.52e-126: 397: 30.18		SOS1_HUMAN (4-464): 6e-117: 374: 18.18
+	Mm
		964561 EGFR_MOUSE (94-606): 1.83e-120: 400: 27.77		SOS1_MOUSE (4-464): 2.07e-115: 369: 17.98
+	Hs
		522935 SRC_HUMAN (1-400): 3.99e-127: 399: 31.42		SOS2_HUMAN (2-464): 1.72e-114: 367: 17.47
+	Hs
		411690 LCK_HUMAN (1-398): 8.72e-125: 391: 30.08		SOS1_HUMAN (4-464): 6e-117: 374: 18.18
+	Hs
		412151 FYN_HUMAN (1-400): 2.52e-126: 397: 30.18		SOS2_HUMAN (2-464): 1.72e-114: 367: 17.47
+	Dm
		644374 SRC42_DROME (1-400): 4.94e-126: 395: 29.46		SOS_DROME (2-457): 5.37e-112: 363: 18.15
+	Hs
		442816 HCK_HUMAN (76-388): 8.7e-112: 358: 34.40		SOS1_HUMAN (4-464): 6e-117: 374: 18.18
+	Hs
		522974 SRC_HUMAN (1-400): 3.99e-127: 399: 31.42		RGRF1_HUMAN (75-445): 6.83e-97: 319: 23.08
+	Hs
		522972 SRC_HUMAN (1-400): 3.99e-127: 399: 31.42		RPGF1_HUMAN (3-459): 8.74e-98: 318: 19.57
+	Hs
		412185 FYN_HUMAN (1-400): 2.52e-126: 397: 30.18		RPGF1_HUMAN (3-459): 8.74e-98: 318: 19.57
+	Hs
		442826 HCK_HUMAN (76-388): 8.7e-112: 358: 34.40		RPGF1_HUMAN (3-459): 8.74e-98: 318: 19.57
+	Hs
		338337 EGFR_HUMAN (105-387): 2.98e-55: 211: 39.58		RGF1B_HUMAN (1-465): 2.08e-153: 446: 67.37
+	Hs
		338323 EGFR_HUMAN (105-387): 2.98e-55: 211: 39.58		SOS1_HUMAN (4-464): 6e-117: 374: 18.18
+	Hs
		338324 EGFR_HUMAN (105-387): 2.98e-55: 211: 39.58		SOS2_HUMAN (2-464): 1.72e-114: 367: 17.47