HitPredict

Interactor 1: ACK1 (Q07912)
Activated CDC42 kinase 1 (ACK-1) (EC 2.7.10.2) (EC 2.7.11.1) (Tyrosine kinase non-receptor protein 2)
Gene: TNK2

Interactor 2: HSH2D (Q96JZ2)
Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X)
Gene: HSH2D

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	25814554, 11700021, unassigned1126
Identification Methods	two hybrid, affinity chromatography technology, enzymatic study, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1038 Hs			1 352
+	Mm
		222864 ACK1_MOUSE (1-1038): 0: 793: 92.70		SH2D7_MOUSE (4-281): 1.8e-67: 220: 25.41
+	Hs
		412152 ACK1_HUMAN (1-1038): 0: 805: 100.00		FYN_HUMAN (3-207): 5.32e-40: 149: 16.81
+	Hs
		433331 ACK1_HUMAN (1-1038): 0: 805: 100.00		YES_HUMAN (2-181): 3.84e-38: 144: 17.07
+	Hs
		522936 ACK1_HUMAN (1-1038): 0: 805: 100.00		SRC_HUMAN (2-207): 1.8e-36: 139: 17.37
+	Hs
		442817 ACK1_HUMAN (1-1038): 0: 805: 100.00		HCK_HUMAN (15-207): 1.82e-35: 137: 17.97
+	Hs
		924513 ACK1_HUMAN (1-1038): 0: 805: 100.00		GRB2_HUMAN (14-150): 1.34e-34: 127: 24.66
+	Hs
		557670 ACK1_HUMAN (1-1038): 0: 805: 100.00		NCK1_HUMAN (1-121): 6.52e-31: 122: 28.46
+	Hs
		992597 ACK1_HUMAN (1-1038): 0: 805: 100.00		P55G_HUMAN (13-130): 1.15e-30: 122: 25.41
+	Mm
		222878 ACK1_MOUSE (1-1038): 0: 793: 92.70		NCK1_MOUSE (1-121): 7.75e-31: 122: 28.46
+	Hs
		209039 ACK1_HUMAN (1-1038): 0: 805: 100.00		NCK2_HUMAN (13-121): 6.71e-23: 100: 29.20
+	Dm
		993220 ACK_DROME (4-1030): 1.31e-167: 522: 30.15		GRAP_DROME (16-129): 6.16e-31: 118: 26.23
+	Mm
		337638 ABL1_MOUSE (1-955): 1.72e-152: 484: 20.27		SHIP1_MOUSE (31-225): 8.68e-36: 140: 22.06
+	Hs
		337307 ABL1_HUMAN (1-955): 4.84e-144: 462: 19.03		FYN_HUMAN (3-207): 5.32e-40: 149: 16.81
+	Mm
		337637 ABL1_MOUSE (1-955): 1.72e-152: 484: 20.27		NCK1_MOUSE (1-121): 7.75e-31: 122: 28.46
+	Hs
		337329 ABL1_HUMAN (1-955): 4.84e-144: 462: 19.03		SRC_HUMAN (2-207): 1.8e-36: 139: 17.37
+	Hs
		337315 ABL1_HUMAN (1-955): 4.84e-144: 462: 19.03		HCK_HUMAN (15-207): 1.82e-35: 137: 17.97
+	Hs
		275157 ABL1_HUMAN (1-955): 4.84e-144: 462: 19.03		GRAP2_HUMAN (3-162): 2.51e-36: 135: 23.21
+	Hs
		337337 ABL1_HUMAN (1-955): 4.84e-144: 462: 19.03		NCK1_HUMAN (1-121): 6.52e-31: 122: 28.46
+	Hs
		337341 ABL1_HUMAN (1-955): 4.84e-144: 462: 19.03		PLCG1_HUMAN (4-147): 2.82e-24: 106: 21.25
+	Hs
		337385 ABL1_HUMAN (1-955): 4.84e-144: 462: 19.03		ZAP70_HUMAN (33-139): 9.19e-17: 83.3: 29.20