HitPredict

Interactor 1: ACK1 (Q07912)
Activated CDC42 kinase 1 (ACK-1) (EC 2.7.10.2) (EC 2.7.11.1) (Tyrosine kinase non-receptor protein 2)
Gene: TNK2

Interactor 2: NED4L (Q96PU5)
E3 ubiquitin-protein ligase NEDD4-like (EC 2.3.2.26) (EC 2.3.2.36) (HECT-type E3 ubiquitin transferase NED4L) (NEDD4.2) (Nedd4-2)
Gene: NEDD4L

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.624

Property	Details
Experiments	19144635, 23686771
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1038 Hs			1 975
+	Mm
		222826 ACK1_MOUSE (1-1038): 0: 793: 92.70		NEDD4_MOUSE (12-975): 0: 794: 55.19
+	Hs
		808104 ACK1_HUMAN (1-1038): 0: 805: 100.00		NEDD4_HUMAN (94-975): 0: 724: 49.78
+	Hs
		125405 ACK1_HUMAN (1-1038): 0: 805: 100.00		WWP2_HUMAN (228-972): 0: 719: 37.80
+	Hs
		337535 ABL1_HUMAN (1-955): 4.84e-144: 462: 19.03		NED4L_HUMAN (1-975): 0: 1033: 100.00
+	Hs
		262307 ULK1_HUMAN (113-957): 7.3e-139: 446: 19.95		NED4L_HUMAN (1-975): 0: 1033: 100.00
+	Hs
		789085 ABL2_HUMAN (1-845): 1.9e-126: 415: 19.68		NED4L_HUMAN (1-975): 0: 1033: 100.00
+	Hs
		1071010 ERBB4_HUMAN (84-754): 3.34e-128: 423: 24.17		WWP1_HUMAN (1-972): 0: 781: 33.13
+	Hs
		1070998 ERBB4_HUMAN (84-754): 3.34e-128: 423: 24.17		ITCH_HUMAN (9-972): 0: 772: 33.16
+	Hs
		337392 ABL1_HUMAN (1-955): 4.84e-144: 462: 19.03		NEDD4_HUMAN (94-975): 0: 724: 49.78
+	Hs
		262241 ULK1_HUMAN (113-957): 7.3e-139: 446: 19.95		NEDD4_HUMAN (94-975): 0: 724: 49.78
+	Hs
		412307 FYN_HUMAN (1-400): 2.52e-126: 397: 30.18		ITCH_HUMAN (9-972): 0: 772: 33.16
+	Hs
		808314 ERRFI_HUMAN (445-889): 3.2e-139: 427: 30.21		NEDD4_HUMAN (94-975): 0: 724: 49.78
+	Hs
		808132 ERBB4_HUMAN (84-754): 3.34e-128: 423: 24.17		NEDD4_HUMAN (94-975): 0: 724: 49.78
+	Hs
		789045 ABL2_HUMAN (1-845): 1.9e-126: 415: 19.68		NEDD4_HUMAN (94-975): 0: 724: 49.78
+	Hs
		433282 YES_HUMAN (1-400): 1.3e-128: 403: 29.93		NEDD4_HUMAN (94-975): 0: 724: 49.78
+	Hs
		522850 SRC_HUMAN (1-400): 3.99e-127: 399: 31.42		NEDD4_HUMAN (94-975): 0: 724: 49.78
+	Hs
		412081 FYN_HUMAN (1-400): 2.52e-126: 397: 30.18		NEDD4_HUMAN (94-975): 0: 724: 49.78
+	Hs
		337496 ABL1_HUMAN (1-955): 4.84e-144: 462: 19.03		HUWE1_HUMAN (358-973): 3.88e-170: 554: 32.26
+	Hs
		992607 ACK1_HUMAN (1-1038): 0: 805: 100.00		SMUF1_HUMAN (17-499): 1.65e-30: 131: 15.71
+	Hs
		992589 ACK1_HUMAN (1-1038): 0: 805: 100.00		HECW1_HUMAN (144-528): 1.92e-09: 64.2: 13.73