HitPredict

Interactor 1: LRP1 (Q07954)
Prolow-density lipoprotein receptor-related protein 1 (LRP-1) (Alpha-2-macroglobulin receptor) (A2MR) (Apolipoprotein E receptor) (APOER) (CD antigen CD91) [Cleaved into: Low-density lipoprotein receptor-related protein 1 85 kDa subunit (LRP-85); Low-density lipoprotein receptor-related protein 1 515 kDa subunit (LRP-515); Low-density lipoprotein receptor-related protein 1 intracellular domain (LRPICD)]
Gene: LRP1

Interactor 2: JIP1 (Q9UQF2)
C-Jun-amino-terminal kinase-interacting protein 1 (JIP-1) (JNK-interacting protein 1) (Islet-brain 1) (IB-1) (JNK MAP kinase scaffold protein 1) (Mitogen-activated protein kinase 8-interacting protein 1)
Gene: MAPK8IP1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.61	0.60	0.609

Property	Details
Experiments	10827173, 20205790
Identification Methods	pull down, two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 4544 Hs			1 711
+	Mm
		1265300 LRP1_MOUSE (24-4544): 0: 3516: 98.08		JIP1_MOUSE (1-711): 0: 995: 93.40
+	Hs
		992682 LRP1_HUMAN (24-4544): 0: 3520: 100.00		ANS1B_HUMAN (424-700): 7.53e-71: 253: 18.60
+	Hs
		992661 LRP1_HUMAN (24-4544): 0: 3520: 100.00		JIP2_HUMAN (25-273): 1.95e-67: 239: 31.92
+	Mm
		1265299 LRP1_MOUSE (24-4544): 0: 3516: 98.08		JIP2_MOUSE (25-274): 1.81e-66: 236: 28.63
+	Hs
		992719 LRP1_HUMAN (24-4544): 0: 3520: 100.00		GULP1_HUMAN (550-701): 8.16e-47: 170: 30.07
+	Hs
		253555 LRP1_HUMAN (24-4544): 0: 3520: 100.00		CAPON_HUMAN (545-707): 1.47e-38: 151: 20.69
+	Hs
		666087 LRP1_HUMAN (24-4544): 0: 3520: 100.00		SHC1_HUMAN (417-700): 6.37e-34: 139: 17.04
+	Mm
		1337450 LRP1B_MOUSE (2-282): 3.55e-13: 79.1: 18.58		JIP1_MOUSE (1-711): 0: 995: 93.40
+	Hs
		957662 LRP2_HUMAN (4062-4370): 5.25e-10: 68.7: 11.50		JIP1_HUMAN (1-711): 0: 955: 100.00
+	Hs
		957621 LRP2_HUMAN (4062-4370): 5.25e-10: 68.7: 11.50		ANS1B_HUMAN (424-700): 7.53e-71: 253: 18.60
+	Mm
		1322325 LRP1B_MOUSE (2-282): 3.55e-13: 79.1: 18.58		JIP2_MOUSE (25-274): 1.81e-66: 236: 28.63
+	Hs
		957599 LRP2_HUMAN (4062-4370): 5.25e-10: 68.7: 11.50		JIP2_HUMAN (25-273): 1.95e-67: 239: 31.92
+	Hs
		253552 LRP2_HUMAN (4062-4370): 5.25e-10: 68.7: 11.50		CAPON_HUMAN (545-707): 1.47e-38: 151: 20.69
+	Hs
		253558 LRP8_HUMAN (4104-4404): 8.77e-10: 67.6: 11.54		CAPON_HUMAN (545-707): 1.47e-38: 151: 20.69
+	Mm
		966336 NOTC1_MOUSE (3253-3657): 4.09e-10: 69.1: 11.79		NUMB_MOUSE (548-704): 1.43e-36: 148: 18.41
+	Hs
		957612 LRP2_HUMAN (4062-4370): 5.25e-10: 68.7: 11.50		ARH_HUMAN (548-706): 2.74e-37: 143: 20.50
+	Dm
		422717 NOTCH_DROME (2434-2789): 1.13e-10: 70.6: 11.72		NUMB_DROME (552-704): 1.2e-34: 141: 20.25
+	Hs
		351073 LDLR_HUMAN (4062-4338): 4.81e-10: 68.3: 11.95		ARH_HUMAN (548-706): 2.74e-37: 143: 20.50
+	Dm
		422847 NOTCH_DROME (2434-2789): 1.13e-10: 70.6: 11.72		Q9VCM6_DROME (542-700): 6.83e-33: 138: 21.26
+	Rn
		88518 LRP2_RAT (4250-4538): 2.9e-10: 69.5: 14.33		ARH_RAT (548-696): 3.42e-34: 134: 20.53