HitPredict

Interactor 1: SRSF1 (Q07955)
Serine/arginine-rich splicing factor 1 (Alternative-splicing factor 1) (ASF-1) (Splicing factor, arginine/serine-rich 1) (pre-mRNA-splicing factor SF2, P33 subunit)
Gene: SRSF1

Interactor 2: DYR1A (Q13627)
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.11.23) (EC 2.7.12.1) (Dual specificity YAK1-related kinase) (HP86) (Protein kinase minibrain homolog) (MNBH) (hMNB)
Gene: DYRK1A

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.69	1.00	0.834

Property	Details
Experiments	14623875, 34316707, 36950384
Identification Methods	enzymatic study, anti bait coimmunoprecipitation
Interaction Type	direct interaction, association

Property	Details
Interacting Pfam domains	Pkinase~RRM_1
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0016607 - nuclear speck GO:0033120 - positive regulation of RNA splicing
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 248 Hs			1 763
+	Hs
		1028543 SRSF9_HUMAN (1-239): 2.72e-66: 206: 60.25		DYR1A_HUMAN (1-763): 0: 613: 100.00
+	Hs
		1028649 SRSF5_HUMAN (14-183): 8.03e-61: 194: 41.48		DYR1A_HUMAN (1-763): 0: 613: 100.00
+	Hs
		1028900 SRSF6_HUMAN (17-200): 2.58e-57: 187: 40.51		DYR1A_HUMAN (1-763): 0: 613: 100.00
+	Hs
		993712 SRSF4_HUMAN (17-243): 1.36e-49: 171: 37.66		DYR1A_HUMAN (1-763): 0: 613: 100.00
+	Hs
		516508 PABP1_HUMAN (8-203): 7.41e-38: 141: 16.67		DYR1A_HUMAN (1-763): 0: 613: 100.00
+	Hs
		951958 SRSF3_HUMAN (15-99): 9.33e-28: 105: 43.53		DYR1A_HUMAN (1-763): 0: 613: 100.00
+	Hs
		1043828 SRSF7_HUMAN (14-105): 7.34e-23: 94.8: 40.22		DYR1A_HUMAN (1-763): 0: 613: 100.00
+	Hs
		1031320 PABP4_HUMAN (118-200): 2.19e-13: 71.2: 16.67		DYR1A_HUMAN (1-763): 0: 613: 100.00
+	Hs
		681823 SRSF5_HUMAN (14-183): 8.03e-61: 194: 41.48		AKT1_HUMAN (38-466): 4.44e-117: 363: 19.42
+	Hs
		516362 PABP1_HUMAN (8-203): 7.41e-38: 141: 16.67		CDK2_HUMAN (156-420): 1.05e-117: 358: 26.85
+	At
		621700 RB45A_ARATH (3-217): 2.68e-27: 109: 14.60		CDKA1_ARATH (156-482): 1.46e-122: 370: 26.65
+	Zm
		11307 C0P488_MAIZE (13-218): 1.31e-27: 110: 11.98		A0A1D6FC67_MAIZE (101-539): 1.02e-118: 365: 23.62
+	Hs
		625466 SRSF7_HUMAN (14-105): 7.34e-23: 94.8: 40.22		CDK2_HUMAN (156-420): 1.05e-117: 358: 26.85
+	Sc
		376610 PABP_YEAST (123-203): 2.42e-12: 68.1: 22.73		YAK1_YEAST (19-586): 3.53e-116: 371: 29.05
+	At
		51039 RSZ33_ARATH (15-110): 4.93e-10: 60.5: 45.83		A1L4Y9_ARATH (129-483): 3.59e-56: 199: 32.90
+	At
		847177 RSZ33_ARATH (15-110): 4.93e-10: 60.5: 45.83		AFC3_ARATH (129-483): 3.59e-56: 199: 32.90
+	Zm
		33400 A0A1D6M1U3_MAIZE (116-219): 4.4e-15: 75.4: 18.52		A0A1D6L2E7_MAIZE (129-479): 1.14e-46: 181: 33.24