HitPredict

Interactor 1: SRSF1 (Q07955)
Serine/arginine-rich splicing factor 1 (Alternative-splicing factor 1) (ASF-1) (Splicing factor, arginine/serine-rich 1) (pre-mRNA-splicing factor SF2, P33 subunit)
Gene: SRSF1

Interactor 2: CLK4 (Q9HAZ1)
Dual specificity protein kinase CLK4 (EC 2.7.12.1) (CDC-like kinase 4)
Gene: CLK4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	34316707
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Pkinase~RRM_1
Common GO terms	GO:0005634 - nucleus GO:0043484 - regulation of RNA splicing
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 248 Hs			1 481
+	Hs
		1028829 SRSF5_HUMAN (14-183): 8.03e-61: 194: 41.48		CLK4_HUMAN (1-481): 3.31e-154: 449: 100.00
+	Hs
		1029103 SRSF6_HUMAN (17-200): 2.58e-57: 187: 40.51		CLK4_HUMAN (1-481): 3.31e-154: 449: 100.00
+	Hs
		833727 SRSF5_HUMAN (14-183): 8.03e-61: 194: 41.48		CLK1_HUMAN (1-480): 1.32e-146: 429: 78.72
+	Hs
		993837 SRSF4_HUMAN (17-243): 1.36e-49: 171: 37.66		CLK4_HUMAN (1-481): 3.31e-154: 449: 100.00
+	Hs
		833728 SRSF6_HUMAN (17-200): 2.58e-57: 187: 40.51		CLK1_HUMAN (1-480): 1.32e-146: 429: 78.72
+	Hs
		833721 SRSF4_HUMAN (17-243): 1.36e-49: 171: 37.66		CLK1_HUMAN (1-480): 1.32e-146: 429: 78.72
+	Hs
		833720 SRSF1_HUMAN (1-235): 1.04e-49: 165: 100.00		CLK1_HUMAN (1-480): 1.32e-146: 429: 78.72
+	Hs
		834031 SRSF5_HUMAN (14-183): 8.03e-61: 194: 41.48		CLK3_HUMAN (8-481): 1.82e-128: 388: 52.19
+	Hs
		833875 SRSF6_HUMAN (17-200): 2.58e-57: 187: 40.51		CLK2_HUMAN (1-481): 3.95e-131: 390: 55.26
+	Hs
		834032 SRSF6_HUMAN (17-200): 2.58e-57: 187: 40.51		CLK3_HUMAN (8-481): 1.82e-128: 388: 52.19
+	Hs
		833871 SRSF4_HUMAN (17-243): 1.36e-49: 171: 37.66		CLK2_HUMAN (1-481): 3.95e-131: 390: 55.26
+	Hs
		834027 SRSF4_HUMAN (17-243): 1.36e-49: 171: 37.66		CLK3_HUMAN (8-481): 1.82e-128: 388: 52.19
+	Hs
		833870 SRSF1_HUMAN (1-235): 1.04e-49: 165: 100.00		CLK2_HUMAN (1-481): 3.95e-131: 390: 55.26
+	Hs
		834026 SRSF1_HUMAN (1-235): 1.04e-49: 165: 100.00		CLK3_HUMAN (8-481): 1.82e-128: 388: 52.19
+	Dm
		834188 Q9V3W7_DROME (11-243): 1.55e-56: 182: 55.65		DOA_DROME (18-480): 2.55e-116: 362: 46.58
+	Hs
		1028543 SRSF9_HUMAN (1-239): 2.72e-66: 206: 60.25		DYR1A_HUMAN (113-476): 2.18e-103: 327: 29.02
+	Hs
		1028649 SRSF5_HUMAN (14-183): 8.03e-61: 194: 41.48		DYR1A_HUMAN (113-476): 2.18e-103: 327: 29.02
+	Hs
		1028900 SRSF6_HUMAN (17-200): 2.58e-57: 187: 40.51		DYR1A_HUMAN (113-476): 2.18e-103: 327: 29.02
+	Hs
		993712 SRSF4_HUMAN (17-243): 1.36e-49: 171: 37.66		DYR1A_HUMAN (113-476): 2.18e-103: 327: 29.02
+	Hs
		992764 SRSF1_HUMAN (1-235): 1.04e-49: 165: 100.00		DYR1A_HUMAN (113-476): 2.18e-103: 327: 29.02