HitPredict

Interactor 1: RHG01 (Q07960)
Rho GTPase-activating protein 1 (CDC42 GTPase-activating protein) (GTPase-activating protein rhoGAP) (Rho-related small GTPase protein activator) (Rho-type GTPase-activating protein 1) (p50-RhoGAP)
Gene: ARHGAP1

Interactor 2: RHOH (Q15669)
Rho-related GTP-binding protein RhoH (GTP-binding protein TTF) (Translocation three four protein)
Gene: RHOH

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ras~RhoGAP
Common GO terms	GO:0005737 - cytoplasm GO:0007264 - small GTPase-mediated signal transduction GO:0031267 - small GTPase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 439 Hs			1 191
+	Hs
		436273 RHG01_HUMAN (1-439): 2.97e-164: 471: 100.00		RHOC_HUMAN (6-185): 6.48e-85: 250: 42.25
+	Hs
		915629 RHG01_HUMAN (1-439): 2.97e-164: 471: 100.00		RHOB_HUMAN (6-191): 6.57e-85: 250: 40.93
+	Hs
		925227 RHG01_HUMAN (1-439): 2.97e-164: 471: 100.00		RAC1_HUMAN (2-191): 2.63e-75: 226: 39.09
+	Mm
		925791 RHG01_MOUSE (1-439): 4.64e-163: 468: 96.58		RAC1_MOUSE (2-191): 2.63e-75: 226: 39.09
+	Hs
		564492 RHG01_HUMAN (1-439): 2.97e-164: 471: 100.00		RHOQ_HUMAN (5-190): 8.15e-74: 222: 39.49
+	Hs
		893937 RHG01_HUMAN (1-439): 2.97e-164: 471: 100.00		CDC42_HUMAN (2-181): 1.52e-73: 221: 42.25
+	Hs
		545341 RHG01_HUMAN (1-439): 2.97e-164: 471: 100.00		RAC2_HUMAN (2-191): 1.96e-72: 218: 38.07
+	Hs
		892334 RHG01_HUMAN (1-439): 2.97e-164: 471: 100.00		RAC3_HUMAN (2-171): 3.86e-72: 218: 41.81
+	Mm
		892723 RHG01_MOUSE (1-439): 4.64e-163: 468: 96.58		CDC42_MOUSE (2-181): 1.52e-73: 221: 42.25
+	Hs
		950946 RHG01_HUMAN (1-439): 2.97e-164: 471: 100.00		RHOG_HUMAN (2-191): 2.32e-71: 216: 37.56
+	Hs
		900412 RHG01_HUMAN (1-439): 2.97e-164: 471: 100.00		RHOA_HUMAN (6-191): 8.9e-71: 214: 39.38
+	Mm
		1125742 RHG01_MOUSE (1-439): 4.64e-163: 468: 96.58		RHOA_MOUSE (6-191): 1.91e-71: 216: 39.90
+	Dm
		776920 RG68F_DROME (42-431): 4.59e-120: 360: 35.93		RAC1_DROME (2-191): 5.11e-73: 220: 38.58
+	Hs
		915737 RHG21_HUMAN (168-434): 3.18e-71: 246: 23.08		RHOB_HUMAN (6-191): 6.57e-85: 250: 40.93
+	Hs
		925343 RHG21_HUMAN (168-434): 3.18e-71: 246: 23.08		RAC1_HUMAN (2-191): 2.63e-75: 226: 39.09
+	Hs
		564562 RHG21_HUMAN (168-434): 3.18e-71: 246: 23.08		RHOQ_HUMAN (5-190): 8.15e-74: 222: 39.49
+	Hs
		894109 RHG21_HUMAN (168-434): 3.18e-71: 246: 23.08		CDC42_HUMAN (2-181): 1.52e-73: 221: 42.25
+	Hs
		545426 RHG21_HUMAN (168-434): 3.18e-71: 246: 23.08		RAC2_HUMAN (2-191): 1.96e-72: 218: 38.07
+	Hs
		892420 RHG21_HUMAN (168-434): 3.18e-71: 246: 23.08		RAC3_HUMAN (2-171): 3.86e-72: 218: 41.81
+	Hs
		900564 RHG21_HUMAN (168-434): 3.18e-71: 246: 23.08		RHOA_HUMAN (6-191): 8.9e-71: 214: 39.38