HitPredict

Interactor 1: GRAP (Q08012)
Growth factor receptor-bound protein 2 (Downstream of receptor kinase) (Protein enhancer of sevenless 2B)
Gene: drk

Interactor 2: DOS (Q9VZZ9)
Protein daughter of sevenless
Gene: DOS

Species: Drosophila melanogaster

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.73	1.00	0.855

Property	Details
Experiments	22028469, 12128212, 35952612
Identification Methods	affinity chromatography technology, solution state nmr, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	PH~SH3_1
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0007165 - signal transduction GO:0007465 - R7 cell fate commitment GO:0008293 - torso signaling pathway and 1 others more... GO:0045500 - sevenless signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 211 Dm			1 878
+	Hs
		924547 GRB2_HUMAN (1-210): 1.39e-64: 200: 62.62		GAB1_HUMAN (3-435): 6.55e-53: 198: 18.71
+	Mm
		1141170 GRB2_MOUSE (1-210): 7.86e-65: 201: 63.08		GAB1_MOUSE (3-435): 2e-50: 191: 18.28
+	Hs
		924640 GRB2_HUMAN (1-210): 1.39e-64: 200: 62.62		PKHA7_HUMAN (4-332): 1.36e-47: 185: 16.38
+	Hs
		924730 GRB2_HUMAN (1-210): 1.39e-64: 200: 62.62		GAB3_HUMAN (3-506): 1.23e-47: 181: 16.85
+	Hs
		846468 BLK_HUMAN (3-190): 1.11e-50: 172: 25.87		GAB1_HUMAN (3-435): 6.55e-53: 198: 18.71
+	Mm
		1141175 GRB2_MOUSE (1-210): 7.86e-65: 201: 63.08		GAB2_MOUSE (229-433): 7.83e-38: 153: 18.30
+	Mm
		1114082 GRB2_MOUSE (1-210): 7.86e-65: 201: 63.08		Q3ZB59_MOUSE (229-433): 9.14e-38: 152: 18.30
+	Hs
		924959 GRB2_HUMAN (1-210): 1.39e-64: 200: 62.62		GAB2_HUMAN (3-221): 8.97e-38: 153: 29.55
+	Mm
		69824 B1AT92_MOUSE (1-210): 2.05e-62: 194: 60.66		GAB2_MOUSE (229-433): 7.83e-38: 153: 18.30
+	Hs
		924876 GRB2_HUMAN (1-210): 1.39e-64: 200: 62.62		PKHA2_HUMAN (5-216): 2.46e-37: 147: 20.64
+	Hs
		1040322 GRAP_HUMAN (1-210): 1.91e-58: 185: 54.17		GAB2_HUMAN (3-221): 8.97e-38: 153: 29.55
+	Hs
		924627 GRB2_HUMAN (1-210): 1.39e-64: 200: 62.62		PKHS1_HUMAN (2-295): 2.31e-32: 133: 19.70
+	Hs
		1035413 VAV3_HUMAN (1-210): 5.76e-35: 132: 21.51		GAB1_HUMAN (3-435): 6.55e-53: 198: 18.71
+	Hs
		855792 VAV2_HUMAN (2-208): 7.42e-35: 132: 21.75		GAB1_HUMAN (3-435): 6.55e-53: 198: 18.71
+	Hs
		557681 NCK1_HUMAN (5-143): 2.4e-20: 89.4: 32.35		GAB1_HUMAN (3-435): 6.55e-53: 198: 18.71
+	Hs
		924651 GRB2_HUMAN (1-210): 1.39e-64: 200: 62.62		MPRIP_HUMAN (8-307): 3.45e-16: 85.4: 15.50
+	Hs
		802588 CRK_HUMAN (48-209): 9e-20: 87: 29.69		GAB1_HUMAN (3-435): 6.55e-53: 198: 18.71
+	Hs
		337512 ABL1_HUMAN (4-138): 2.7e-23: 99: 36.43		GAB3_HUMAN (3-506): 1.23e-47: 181: 16.85
+	Dm
		993229 GRAP_DROME (1-211): 8.97e-63: 195: 100.00		X2JFU3_DROME (1-108): 9.37e-14: 74.5: 25.93
+	Hs
		557834 NCK1_HUMAN (5-143): 2.4e-20: 89.4: 32.35		GAB2_HUMAN (3-221): 8.97e-38: 153: 29.55