HitPredict

Interactor 1: ACTN3 (Q08043)
Alpha-actinin-3 (Alpha-actinin skeletal muscle isoform 3) (F-actin cross-linking protein)
Gene: ACTN3

Interactor 2: MILK1 (Q8N3F8)
MICAL-like protein 1 (Molecule interacting with Rab13) (MIRab13)
Gene: MICALL1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	CH~bMERB_dom, CH~CH, CH~EFhand_Ca_insen, CH~Spectrin
Common GO terms	GO:0030036 - actin cytoskeleton organization
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 901 Hs			1 863
+	Hs
		521530 ACTN1_HUMAN (19-901): 0: 687: 77.82		ACTN3_HUMAN (3-227): 6.27e-66: 239: 31.56
+	Hs
		70398 ACTN1_HUMAN (19-901): 0: 687: 77.82		B2R8Y4_HUMAN (3-227): 7.25e-66: 239: 32.00
+	Hs
		70394 B2R8Y4_HUMAN (1-901): 0: 684: 99.45		B2R8Y4_HUMAN (3-227): 7.25e-66: 239: 32.00
+	Hs
		521452 ACTN1_HUMAN (19-901): 0: 687: 77.82		ACTN1_HUMAN (3-227): 1.28e-64: 235: 29.78
+	Hs
		211478 ACTN1_HUMAN (19-901): 0: 687: 77.82		ACTN4_HUMAN (3-227): 5.94e-64: 233: 29.78
+	Hs
		521485 ACTN1_HUMAN (19-901): 0: 687: 77.82		ACTN2_HUMAN (3-227): 5.02e-64: 233: 30.22
+	Hs
		993246 ACTN3_HUMAN (1-901): 0: 680: 100.00		ACTN3_HUMAN (3-227): 6.27e-66: 239: 31.56
+	Hs
		70396 B2R8Y4_HUMAN (1-901): 0: 684: 99.45		ACTN4_HUMAN (3-227): 5.94e-64: 233: 29.78
+	Hs
		211571 ACTN3_HUMAN (1-901): 0: 680: 100.00		ACTN4_HUMAN (3-227): 5.94e-64: 233: 29.78
+	Hs
		725648 ACTN3_HUMAN (1-901): 0: 680: 100.00		ACTN2_HUMAN (3-227): 5.02e-64: 233: 30.22
+	Rn
		1167662 ACTN1_RAT (19-901): 0: 688: 77.48		Q6XD99_RAT (3-246): 8.28e-57: 215: 28.69
+	Hs
		521573 ACTN1_HUMAN (19-901): 0: 687: 77.82		MILK2_HUMAN (7-836): 5.02e-57: 213: 30.82
+	Hs
		725624 ACTN2_HUMAN (13-901): 0: 663: 79.98		ACTN2_HUMAN (3-227): 5.02e-64: 233: 30.22
+	Hs
		993273 ACTN3_HUMAN (1-901): 0: 680: 100.00		MILK2_HUMAN (7-836): 5.02e-57: 213: 30.82
+	Hs
		725674 ACTN2_HUMAN (13-901): 0: 663: 79.98		MILK2_HUMAN (7-836): 5.02e-57: 213: 30.82