HitPredict

Interactor 1: HRD1 (Q08109)
ERAD-associated E3 ubiquitin-protein ligase HRD1 (EC 2.3.2.27) (HMG-CoA reductase degradation protein 1) (RING-type E3 ubiquitin transferase HRD1)
Gene: HRD1

Interactor 2: HRD1 (Q08109)
ERAD-associated E3 ubiquitin-protein ligase HRD1 (EC 2.3.2.27) (HMG-CoA reductase degradation protein 1) (RING-type E3 ubiquitin transferase HRD1)
Gene: HRD1

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.97 1.00 0.986

The method score is based on:

Property Details
Experiments 11724934, 11146622, 25646477, 27321670, 27170191, 28682307, 25215493, 32327568, 32094691, 35970394, 37066402, 21074049, 19394298, 23665230, 11139575, 19366730
Identification Methods pull down, enzymatic study, affinity chromatography technology, x-ray crystallography, cross-linking study, anti tag coimmunoprecipitation, molecular sieving
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains zf-RING_2~zf-RING_2
Common GO terms GO:0000836 - Hrd1p ubiquitin ligase complex
GO:0000838 - Hrd1p ubiquitin ligase ERAD-M complex
GO:0000839 - Hrd1p ubiquitin ligase ERAD-L complex
GO:0004842 - ubiquitin-protein transferase activity
GO:0005737 - cytoplasm
and 11 others

more...
Homologous interactions 16

Homologous interactions

Color coding for hit scores

1 551
Sc

1 551
+ Hs
+ At
+ At
+ Hs
+ Zm
+ Hs
+ Hs
+ Hs
+ Ce
+ Mm
+ Hs
+ Hs
+ Hs
+ Sc
+ Hs
+ Hs

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Last updated: 15 Jul 2024