HitPredict

Interactor 1: TLE5 (Q08117)
TLE family member 5 (Amino-terminal enhancer of split) (Amino enhancer of split) (Gp130-associated protein GAM) (Grg-5) (Groucho-related protein 5) (Protein ESP1) (Protein GRG) (TLE family member 5, transcriptional modulator)
Gene: TLE5

Interactor 2: Q5JSZ1 (Q5JSZ1)
TLE family member 4, transcriptional corepressor
Gene: TLE4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	28514442
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	TLE_N~TLE_N
Common GO terms	GO:0003714 - transcription corepressor activity GO:0005634 - nucleus GO:0005667 - transcription regulator complex GO:0016055 - Wnt signaling pathway GO:0090090 - negative regulation of canonical Wnt signaling pathway
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 197 Hs			1 224
+	Mm
		1143962 TLE4_MOUSE (2-191): 3.77e-112: 338: 68.59		TLE4_MOUSE (1-214): 5.28e-120: 360: 92.06
+	Hs
		980586 TLE4_HUMAN (2-191): 3.57e-112: 338: 68.59		TLE1_HUMAN (8-214): 2.52e-110: 335: 81.73
+	Hs
		980583 TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50		TLE1_HUMAN (8-214): 2.52e-110: 335: 81.73
+	Hs
		980770 TLE3_HUMAN (2-197): 3.95e-105: 320: 61.50		Q5JSZ1_HUMAN (1-224): 2.09e-117: 335: 100.00
+	Hs
		980730 TLE4_HUMAN (2-191): 3.57e-112: 338: 68.59		TLE3_HUMAN (8-215): 2.07e-100: 309: 74.41
+	Hs
		980585 TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50		TLE3_HUMAN (8-215): 2.07e-100: 309: 74.41
+	Hs
		980729 TLE3_HUMAN (2-197): 3.95e-105: 320: 61.50		TLE3_HUMAN (8-215): 2.07e-100: 309: 74.41
+	Hs
		980772 TLE3_HUMAN (2-197): 3.95e-105: 320: 61.50		Q5T3G3_HUMAN (8-214): 5.99e-102: 296: 81.73
+	Mm
		1143956 TLE1_MOUSE (2-197): 2.15e-101: 310: 63.00		TLE1_MOUSE (8-215): 9.86e-99: 305: 80.38
+	Mm
		925830 TLE4_MOUSE (2-191): 3.77e-112: 338: 68.59		TLE5_MOUSE (8-213): 1.28e-86: 256: 63.11
+	Hs
		980928 TLE4_HUMAN (2-191): 3.57e-112: 338: 68.59		TLE5_HUMAN (8-213): 2.01e-86: 255: 63.11
+	Hs
		980590 TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50		TLE5_HUMAN (8-213): 2.01e-86: 255: 63.11
+	Hs
		980674 TLE4_HUMAN (2-191): 3.57e-112: 338: 68.59		TLE2_HUMAN (8-169): 6.96e-76: 244: 74.69
+	Hs
		980584 TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50		TLE2_HUMAN (8-169): 6.96e-76: 244: 74.69
+	Hs
		980734 TLE3_HUMAN (2-197): 3.95e-105: 320: 61.50		TLE5_HUMAN (8-213): 2.01e-86: 255: 63.11
+	Mm
		925829 TLE1_MOUSE (2-197): 2.15e-101: 310: 63.00		TLE5_MOUSE (8-213): 1.28e-86: 256: 63.11
+	Hs
		980673 TLE3_HUMAN (2-197): 3.95e-105: 320: 61.50		TLE2_HUMAN (8-169): 6.96e-76: 244: 74.69