HitPredict

Interactor 1: TLE5 (Q08117)
TLE family member 5 (Amino-terminal enhancer of split) (Amino enhancer of split) (Gp130-associated protein GAM) (Grg-5) (Groucho-related protein 5) (Protein ESP1) (Protein GRG) (TLE family member 5, transcriptional modulator)
Gene: TLE5

Interactor 2: ARX (Q96QS3)
Homeobox protein ARX (Aristaless-related homeobox)
Gene: ARX

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	0.60	0.541

Property	Details
Experiments	21653829
Identification Methods	two hybrid, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 197 Hs			1 562
+	Hs
		641379 TLE4_HUMAN (2-191): 3.57e-112: 338: 68.59		PAX6_HUMAN (272-508): 4.6e-43: 160: 26.62
+	Hs
		641377 TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50		PAX6_HUMAN (272-508): 4.6e-43: 160: 26.62
+	Hs
		620144 TLE4_HUMAN (2-191): 3.57e-112: 338: 68.59		PAX7_HUMAN (111-556): 5.65e-40: 154: 21.29
+	Hs
		980644 TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50		BARH1_HUMAN (267-466): 3.11e-42: 156: 29.05
+	Hs
		620142 TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50		PAX7_HUMAN (111-556): 5.65e-40: 154: 21.29
+	Mm
		623700 TLE4_MOUSE (2-191): 3.77e-112: 338: 68.59		PAX3_MOUSE (111-556): 1.56e-36: 144: 22.76
+	Hs
		641378 TLE3_HUMAN (2-197): 3.95e-105: 320: 61.50		PAX6_HUMAN (272-508): 4.6e-43: 160: 26.62
+	Hs
		620143 TLE3_HUMAN (2-197): 3.95e-105: 320: 61.50		PAX7_HUMAN (111-556): 5.65e-40: 154: 21.29
+	Hs
		980936 TLE4_HUMAN (2-191): 3.57e-112: 338: 68.59		ISX_HUMAN (287-474): 6.58e-35: 133: 32.12
+	Hs
		980618 TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50		ISX_HUMAN (287-474): 6.58e-35: 133: 32.12
+	Hs
		822627 TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50		LHX1_HUMAN (259-530): 1.51e-32: 131: 19.41
+	Hs
		980762 TLE3_HUMAN (2-197): 3.95e-105: 320: 61.50		ISX_HUMAN (287-474): 6.58e-35: 133: 32.12
+	Hs
		641385 TLE5_HUMAN (1-197): 3.1e-101: 292: 100.00		PAX6_HUMAN (272-508): 4.6e-43: 160: 26.62
+	Hs
		620146 TLE5_HUMAN (1-197): 3.1e-101: 292: 100.00		PAX7_HUMAN (111-556): 5.65e-40: 154: 21.29
+	Hs
		993568 TLE5_HUMAN (1-197): 3.1e-101: 292: 100.00		PITX2_HUMAN (282-556): 3.16e-36: 139: 25.82
+	Hs
		993441 TLE5_HUMAN (1-197): 3.1e-101: 292: 100.00		ISX_HUMAN (287-474): 6.58e-35: 133: 32.12
+	Hs
		941895 TLE5_HUMAN (1-197): 3.1e-101: 292: 100.00		PITX1_HUMAN (239-544): 1.35e-30: 123: 25.16
+	Hs
		980714 TLE2_HUMAN (2-149): 6.71e-80: 253: 71.62		BARH1_HUMAN (267-466): 3.11e-42: 156: 29.05
+	Ce
		137665 UNC37_CAEEL (18-160): 8.43e-43: 153: 28.47		UNC4_CAEEL (238-461): 4.33e-33: 128: 30.80