HitPredict

Interactor 1: SRSF4 (Q08170)
Serine/arginine-rich splicing factor 4 (Pre-mRNA-splicing factor SRP75) (SRP001LB) (Splicing factor, arginine/serine-rich 4)
Gene: SRSF4

Interactor 2: CPSF7 (Q8N684)
Cleavage and polyadenylation specificity factor subunit 7 (Cleavage and polyadenylation specificity factor 59 kDa subunit) (CPSF 59 kDa subunit) (Cleavage factor Im complex 59 kDa subunit) (CFIm59) (Pre-mRNA cleavage factor Im 59 kDa subunit)
Gene: CPSF7

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.621

Property	Details
Experiments	34133714
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 494 Hs			1 471
+	Hs
		992845 SRSF1_HUMAN (3-166): 2.36e-57: 192: 41.42		CPSF7_HUMAN (1-456): 1.39e-122: 367: 100.00
+	Hs
		992791 SRSF1_HUMAN (3-166): 2.36e-57: 192: 41.42		CPSF6_HUMAN (1-451): 1.98e-76: 250: 39.51
+	Hs
		1028937 SRSF6_HUMAN (1-180): 4.52e-52: 181: 78.50		CPSF6_HUMAN (1-451): 1.98e-76: 250: 39.51
+	Hs
		1028560 SRSF9_HUMAN (3-216): 2.36e-52: 178: 36.53		CPSF6_HUMAN (1-451): 1.98e-76: 250: 39.51
+	Mm
		1112117 SRSF6_MOUSE (1-200): 5.39e-48: 170: 74.76		CPSF6_MOUSE (1-451): 8.75e-77: 251: 39.51
+	Mm
		1156792 RBM4_MOUSE (1-218): 3.79e-19: 90.8: 23.85		CPSF6_MOUSE (1-451): 8.75e-77: 251: 39.51
+	Hs
		1084591 RBM4B_HUMAN (3-104): 4.68e-11: 66.1: 23.08		CPSF6_HUMAN (1-451): 1.98e-76: 250: 39.51
+	Sc
		376750 NOP4_YEAST (1-492): 1.19e-52: 190: 11.82		PABP_YEAST (83-159): 2.45e-16: 83.4: 24.68
+	Hs
		516478 SRSF1_HUMAN (3-166): 2.36e-57: 192: 41.42		PABP1_HUMAN (73-165): 7.95e-10: 63: 19.36
+	Hs
		516493 SRSF9_HUMAN (3-216): 2.36e-52: 178: 36.53		PABP1_HUMAN (73-165): 7.95e-10: 63: 19.36
+	Cn
		111495 J9VJ75_CRYNH (3-179): 9.05e-43: 161: 30.85		J9VUR9_CRYNH (83-158): 3.66e-10: 64.2: 21.05
+	Hs
		516689 PABP1_HUMAN (1-189): 4.04e-31: 128: 19.50		PABP3_HUMAN (83-184): 4.77e-13: 73.4: 19.61
+	Hs
		516495 PABP1_HUMAN (1-189): 4.04e-31: 128: 19.50		PABP4_HUMAN (73-165): 2.96e-11: 67.6: 18.28
+	Sc
		376649 GBP2_YEAST (4-201): 2.69e-25: 109: 20.19		PABP_YEAST (83-159): 2.45e-16: 83.4: 24.68
+	Hs
		516339 PABP1_HUMAN (1-189): 4.04e-31: 128: 19.50		PABP1_HUMAN (73-165): 7.95e-10: 63: 19.36
+	Sc
		376562 PABP_YEAST (72-188): 2.61e-10: 64.6: 14.75		PABP_YEAST (83-159): 2.45e-16: 83.4: 24.68
+	Hs
		474021 PAB4L_HUMAN (100-185): 1.44e-10: 65: 19.78		PABP4_HUMAN (73-165): 2.96e-11: 67.6: 18.28
+	Hs
		516471 TIAR_HUMAN (96-188): 2.66e-10: 63.8: 16.67		PABP1_HUMAN (73-165): 7.95e-10: 63: 19.36